88933-16-8

Basic information

• Product Name: N-Methyl-4-diazanylsulfabenzamide
• Synonyms: P-HYDRAZINO-N-METHYLBENZENEMETHANESULFONAMIDE HYDROCHLORIDE;n-methyl-4-diazanylsulfabenzamide;N-METHYL-4-DIAZANYL TOLUENE SULFAMINE HCL;4-HYDRAZINE-N-METHYL-BENZENEMETHANESULFONAMIDE HCL;4-HYDRAZINO-N-METHYL BENZENE METHANE SULFONAMIDE HCL;4-HYDRAZINO-N-METHYLBENZENEMETHANESULFONAMIDE MONOHYDROCHLORIDE;N-Methyl-4-Diazanyl Toluene Sulfamine;N-Methyl-4-diazanylsulfabenzamide hydrochloride
• CAS NO: 88933-16-8
• Molecular Formula: C8H14ClN3O2S
• Molecular Weight: 251.73
• Product Categories: Aromatics Compounds;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Other Products
• Mol File: 88933-16-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 170-173°C
• Boiling Point: 427.4 °C at 760 mmHg
• Flash Point: 212.3 °C
• Appearance: Pale yellow solid
• Density: 1.356 g/cm³
• Vapor Pressure: 1.85E-08mmHg at 25°C
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly, Heated, Sonicated), Water (Slightly)
• CAS DataBase Reference: N-Methyl-4-diazanylsulfabenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Methyl-4-diazanylsulfabenzamide(88933-16-8)
• EPA Substance Registry System: N-Methyl-4-diazanylsulfabenzamide(88933-16-8)

Safety Data

• Hazardous Substances Data: 88933-16-8(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Solid

Uses

4-Hydrazino-N-methylbenzenemethanesulfonamide is an intermediate for preparation of Sumatriptan (S810000).

InChI:InChI=1/C8H13N3O2S.ClH/c1-10-14(12,13)6-7-2-4-8(11-9)5-3-7;/h2-5,10-11H,6,9H2,1H3;1H

Upstream product

• 109903-35-7 1-(4-aminophenyl)-N-methylmethanesulfonamide 

Downstream Products

• 151140-96-4 avitriptan 

Relevant articles and documents

Synthesis of n-methyl benzenemethane sulfonamide substituted carbazoles and pyrazoles

Cyclization of 1-(4-hydrazinophenyl)-N-methylmethanesulfonamide hydrochloride (2) with cyclohexanone (3)/N-methyl-4-piperidone (5) afforded the corresponding N-methyl-1-(2,3,4,9-tetrahydro-1H-carbazol-6-yl)methanesulfonamide (4) and N-methyl-1-(2-methyl- 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl) methane sulfonamide (6). Condensation of compound 2 with substituted aryl β-diketones gave the novel N-methyl-1-[4-(3-methyl-5-phenyl-1H-pyrazol-1- yl)phenyl]methanesulfonamide (8). All the synthesized compounds were characterized by their FT-IR, 1H NMR and mass spectral data.

Piperazine, piperidine and tetrahydropyridine derivatives useful as 5-HT1 recepter agonists

A class of N-substituted piperazine, piperadine and tetrahyrdopyridine derivatives of formula (I), further substituted at the 4-position by an optionally substituted aryl-alkyl or heteroaryl-alkyl moiety, are selective agonists of 5-HT1 -like r