890043-61-5

Basic information

• Product Name: (S)-2-(tert-butoxycarbonylaminophenylmethyl)malonic acid dibenzyl ester
• Synonyms: (S)-2-(tert-butoxycarbonylaminophenylmethyl)malonic acid dibenzyl ester
• CAS NO: 890043-61-5
• Molecular Weight: 489.568
• Mol File: 890043-61-5.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: (S)-2-(tert-butoxycarbonylaminophenylmethyl)malonic acid dibenzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-(tert-butoxycarbonylaminophenylmethyl)malonic acid dibenzyl ester(890043-61-5)
• EPA Substance Registry System: (S)-2-(tert-butoxycarbonylaminophenylmethyl)malonic acid dibenzyl ester(890043-61-5)

Safety Data

• Hazardous Substances Data: 890043-61-5(Hazardous Substances Data)

Upstream product

• 15014-25-2 malonic acid dibenzyl ester 
• 155396-71-7 tert-butyl N-(phenyl(phenylsulfonyl)methyl)carbamate 
• 150884-50-7 benzaldehyde N-boc imine 
• 1396512-33-6 1-(phenylethynyl)naphthalen-2-ol 
• 4248-19-5 tert-butyl carbazate 
• 100-52-7 benzaldehyde 
• 177896-09-2 tert-butyl benzylidenecarbamate 

Downstream Products

• 83649-47-2 (S)-(-)-β-Phenyl-β-alanine hydrochloride 
• 135865-78-0 tert-butyl (1S)-3-oxo-1-phenylpropylcarbamate 
• 190189-97-0 methyl (3S)-3-[(tert-butoxycarbonyl)amino]-3-phenylpropionate 
• 376348-65-1 maraviroc 
• 376348-71-9 (S)-3-((1R,3R,5S)-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl)-1-phenylpropan-1-amine 
• 376348-70-8 tert-butyl (1S)-3-[3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-exo-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropylcarbamate 
• 161024-80-2 (R)-3-((tert-butoxycarbonyl)amino)-3-phenylpropanoic acid 
• 103365-47-5 (S)-3-(tert-butoxycarbonylamino)-3-phenylpropanoic acid 

Relevant articles and documents

The Mannich reaction of malonates with simple imines catalyzed by bifunctional cinchona alkaloids: Enantioselective synthesis of β-amino acids

We describe the first efficient, direct asymmetric Mannich reactions with malonates and N-Boc aryl and alkyl imines by cooperative hydrogen-bonding catalysis with a cinchona alkaloid bearing a thiourea functionality. We have also extended the scope of thi

METHOD FOR SYNTHESIZING β-AMINO-DITHIOESTER COMPOUND AND β-AMINO-DITHIOESTER COMPOUND SYNTHESIZED BY THE METHOD

Disclosed is a production method of an N-protected-beta-amino-dithioester compound. To produce the N-protected-andbeta;-amino-dithioester compound, dithiomalonate may asymmetrically react with N-protected-imine or N-protected-alpha-amidosulfone according to the Mannich reaction in the presence of a chiral catalyst comprising a quaternary amide functional group and a quinuclidine functional group. According to the production method, chiral N-protected-beta-amino-dithioester can be synthesized with high optical selectivity at a high yield using a catalyst which is remarkably inexpensive and safe as compared with conventional metal catalysts.COPYRIGHT KIPO 2017

Asymmetric dual-reagent catalysis: Mannich-type reactions catalyzed by ion pair

The combination of a new bifunctional phosphine and an acrylate generate a zwitterion in situ and it serves as an efficient catalyst for asymmetric reactions through a homogeneous ion-pairing mode. This new catalytic system has been successfully applied t