89026-78-8

Basic information

• Product Name: 6-CHLORO-N-METHYLPYRIDIN-2-AMINE
• Synonyms: 6-CHLORO-N-METHYLPYRIDIN-2-AMINE;6-Chloro-N-methylpyridine-2-amine;2-PyridinaMine, 6-chloro-N-Methyl-;(6-Chloro-pyridin-2-yl)-Methyl-aMine;6-Chloro-2-methylaminopyridine
• CAS NO: 89026-78-8
• Molecular Formula: C₆H₇ClN₂
• Molecular Weight: 142.59
• Mol File: 89026-78-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 253.3±20.0 °C(Predicted)
• Appearance: /
• Density: 1.250±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 3.20±0.10(Predicted)
• CAS DataBase Reference: 6-CHLORO-N-METHYLPYRIDIN-2-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLORO-N-METHYLPYRIDIN-2-AMINE(89026-78-8)
• EPA Substance Registry System: 6-CHLORO-N-METHYLPYRIDIN-2-AMINE(89026-78-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 89026-78-8(Hazardous Substances Data)

Usage

General Description

6-Chloro-N-methylpyridin-2-amine, also known as 6-Chloronicotinylamine or 6-Chloro-2-aminomethylpyridine, is an organic compound with the molecular formula C6H7ClN2. It is a chlorinated derivative of pyridine and contains a methyl group and an amine group. This chemical is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has also been studied for its potential as a building block in the development of new chemical compounds. 6-Chloro-N-methylpyridin-2-amine may pose certain health and environmental hazards and should be handled and disposed of with proper safety measures in place.

InChI:InChI=1S/C6H7ClN2/c1-8-6-4-2-3-5(7)9-6/h2-4H,1H3,(H,8,9)

Upstream product

• 45644-21-1 6-chloropyridin-2-amine 
• 67-56-1 methanol 
• 2402-78-0 2,6-dichloropyridine 
• 74-89-5 methylamine 

Downstream Products

• 881208-62-4 N-methyl-6-phenylpyridin-2-amine 

Relevant articles and documents

Method for catalyzing N-alkylation of aminopyridine

The invention discloses a method for catalyzing N-alkylation of aminopyridine. The method comprises the step of reacting an aminopyridine compound with an alkylation raw material in the presence of a heterogeneous catalyst to obtain an N-alkylated aminopyridine compound. The alkylation reaction has high activity and selectivity, is simple to operate and low in catalyst price, does not need other reaction steps, is beneficial to large-scale industrial production, and compared with previous reports, does not need to use a large amount of noble metals, can be continuously carried out, and does not use other expensive organic raw materials or reducing agents in the process. Generation of a large amount of organic waste liquid and solid waste is avoided, and collection operation of process products is simple.

A practical synthesis of substituted 2,6-diaminopyridines via microwave-assisted copper-catalyzed amination of halopyridines

A microwave assisted copper-catalyzed amination protocol is reported utilizing a series of 2,6-dihalo- and 2-amino-6-halo pyridine precursors. Using this procedure, selective substitution of one or two halogens by aryl or alkylamines was achieved within 2-6 h with temperatures between 80 and 225 °C affording 2,6-diaminopyridines in good to excellent isolated yields. The reaction allows easy variation between educts and different N-substitutions. The target compounds are valuable precursors for the synthesis of bis-phosphorylated 2,6-diaminopyridines which are used as PNP pincer ligands in transition metal complexes.

2-Alkylaminopyridine derivatives

2-Alkylaminopyridine derivatives represented by a general formula of STR1 wherein R denotes a lower alkyl group and Y denotes a methoxy group or a halogen atom, and method for producing the same.