Welcome to LookChem.com Sign In|Join Free

CAS

  • or

891494-64-7

Post Buying Request

891494-64-7 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

891494-64-7 Usage

Description

SCH-900776, also known as 6-Bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(3S)-3-piperidinylpyrazolo[1,5-a]pyrimidin-7-amine, is a protein kinase inhibitor with potential therapeutic applications in the treatment of protein kinase-mediated diseases.

Uses

Used in Pharmaceutical Industry:
SCH-900776 is used as a protein kinase inhibitor for the treatment of protein kinase-mediated diseases. Its ability to inhibit protein kinases makes it a promising candidate for the development of targeted therapies against various diseases driven by abnormal protein kinase activity.

Check Digit Verification of cas no

The CAS Registry Mumber 891494-64-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,9,1,4,9 and 4 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 891494-64:
(8*8)+(7*9)+(6*1)+(5*4)+(4*9)+(3*4)+(2*6)+(1*4)=217
217 % 10 = 7
So 891494-64-7 is a valid CAS Registry Number.

891494-64-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-bromo-3-(1-methylpyrazol-4-yl)-5-[(3S)-piperidin-3-yl]pyrazolo[1,5-a]pyrimidin-7-amine

1.2 Other means of identification

Product number -
Other names CS-1119

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:891494-64-7 SDS

891494-64-7Downstream Products

891494-64-7Relevant articles and documents

A convergent preparation of the CHK1 inhibitor MK-8776 (SCH 900776)

Labroli, Marc A.,Dwyer, Michael P.,Poker, Cory,Keertikar, Kerry M.,Rossman, Randall,Guzi, Timothy J.

, p. 2601 - 2603 (2016/06/01)

This Letter describes the development of a convergent, efficient route to the CHK1 inhibitor MK-8776. This synthetic approach relies upon the cyclization of a bispyrazole adduct 10 with a optically pure β-keto nitrile 9 to construct the pyrazolo[1,5-a]pyrimidine scaffold in a single step.

COMPOSITIONS AND METHODS FOR TREATING CANCER

-

, (2013/03/28)

The instant invention provides a method of treating a cancer, selected from the group consisting of breast cancer, melanoma, colorectal cancer, non-small cell lung cancer and ovarian cancer, by administering a combination of a WEE1 inhibitor and a CHK1 inhibitor, wherein the WEE1 inhibitor is MK-1775 or a pharmaceutically acceptable salt thereof, or MK-3652 or a pharmaceutically acceptable salt thereof, and the CHK1 inhibitor is MK-8776 or a pharmaceutically acceptable salt thereof, or SCH900444 or a pharmaceutically acceptable salt thereof.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 891494-64-7