89185-45-5 Usage
General Description
7-METHYL-2-PHENYLIMIDAZO[1,2-A]PYRIDIN-3-AMINE, also known as MPI-0479605, is a chemical compound that belongs to the imidazo[1,2-a]pyridine family. It is a kinase inhibitor, specifically targeting a type of protein called ERK5, which is involved in the regulation of cell growth and proliferation. By inhibiting ERK5, this compound has the potential to disrupt the growth of cancer cells and is being studied for its anti-cancer properties. Additionally, it may have applications in the treatment of inflammatory and cardiovascular diseases, as the ERK5 pathway is also involved in these physiological processes. Its unique structure and mechanism of action make 7-METHYL-2-PHENYLIMIDAZO[1,2-A]PYRIDIN-3-AMINE a promising candidate for further drug development and research.
Check Digit Verification of cas no
The CAS Registry Mumber 89185-45-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,9,1,8 and 5 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 89185-45:
(7*8)+(6*9)+(5*1)+(4*8)+(3*5)+(2*4)+(1*5)=175
175 % 10 = 5
So 89185-45-5 is a valid CAS Registry Number.
InChI:InChI=1/C14H13N3/c1-10-7-8-17-12(9-10)16-13(14(17)15)11-5-3-2-4-6-11/h2-9H,15H2,1H3
89185-45-5Relevant articles and documents
Photoinduced, Direct C(sp2)?H Bond Azo Coupling of Imidazoheteroarenes and Imidazoanilines with Aryl Diazonium Salts Catalyzed by Eosin Y
Saba, Sumbal,Dos Santos, Caio R.,Zavarise, Bruno R.,Naujorks, Aline A. S.,Franco, Marcelo S.,Schneider, Alex R.,Scheide, Marcos R.,Affeldt, Ricardo F.,Rafique, Jamal,Braga, Antonio L.
, p. 4461 - 4466 (2020/02/25)
Herein, a greener approach to the eosin Y-Na2 catalyzed, C(sp2)?H bond azo coupling of imidazoheteroarene with aryl diazonium salts is described, under acid free conditions. This direct photoredox process resulted in the corresponding azo products in good to excellent yields. Besides, this new approach could also be applicable to anilines, which is a poorly reactive substrate by other methods. The main features of this reaction are that it provides high yields and is gram-scalable and applicable to biologically relevant imidazoheteroarenes and -anilines.
