89238-99-3

Basic information

• Product Name: 4-METHOXYBENZYL-2,2,2-TRICHLOROACETIMID&
• Synonyms: 4-METHOXYBENZYL-2,2,2-TRICHLOROACETIMID&;2,2,2-Trichloroacetimidic Acid 4-Methoxybenzyl Ester;4-Methoxybenzyl 2,2,2-Trichloroacetimidate;4-Methoxybenzyl trichloroacetimidate;4-methoxybenzyl 2,2,2-trichloroethanimidoate
• CAS NO: 89238-99-3
• Molecular Formula: C₁₀H₁₀Cl₃NO₂
• Molecular Weight: 282.55
• Product Categories: Protection & Derivatization Reagents (for Synthesis);Synthetic Organic Chemistry;Others;Protecting and Derivatizing Reagents;Protection and Derivatization
• Mol File: 89238-99-3.mol
• Article Data: 78

Chemical Properties

• Boiling Point: 137 °C / 0.7mmHg
• Flash Point: 110 °C
• Appearance: /
• Density: 1.361 g/mL at 25 °C
• Vapor Pressure: 0.000103mmHg at 25°C
• Refractive Index: n20/D 1.5488
• Storage Temp.: Refrigerator
• PKA: 1.96±0.70(Predicted)
• CAS DataBase Reference: 4-METHOXYBENZYL-2,2,2-TRICHLOROACETIMID&(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHOXYBENZYL-2,2,2-TRICHLOROACETIMID&(89238-99-3)
• EPA Substance Registry System: 4-METHOXYBENZYL-2,2,2-TRICHLOROACETIMID&(89238-99-3)

Safety Data

• Hazard Codes: Xn,N
• Statements: 20/21/22-36/37/38-51/53
• Safety Statements: 26-61-36/37
• RIDADR: UN 3082 9/PG 3
• WGK Germany: 3
• Hazardous Substances Data: 89238-99-3(Hazardous Substances Data)

Usage

General Description

4-Methoxybenzyl-2,2,2-trichloroacetimid is a chemical compound with the formula C11H11Cl3NO2. It is a trichloroacetimid derivative of 4-methoxybenzyl alcohol, and it is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 4-METHOXYBENZYL-2,2,2-TRICHLOROACETIMID& has various industrial applications, including its use as a building block in the production of pesticides, herbicides, and insecticides. Additionally, it is known for its insecticidal and acaricidal properties, making it a valuable compound in the agricultural and chemical industries. Furthermore, 4-methoxybenzyl-2,2,2-trichloroacetimid is also used in the synthesis of various pharmaceuticals, especially in the development of new drugs.

InChI:InChI=1/C10H10Cl3NO2/c1-15-8-4-2-7(3-5-8)6-16-9(14)10(11,12)13/h2-5,14H,6H2,1H3

Upstream product

• 545-06-2 trichloroacetonitrile 
• 105-13-5 4-Methoxybenzyl alcohol 

Downstream Products

• 135362-69-5 3-(4-methoxybenzyl)oxypropan-1-ol 
• 170649-26-0 (S)-3-(4-Methoxy-benzyloxy)-butyric acid ethyl ester 
• 212051-35-9 (R)-methyl 3-((4-methoxybenzyl)oxy)-2-methylpropanoate 
• 847229-99-6 C₇₇H₉₁NO₁₅Si 
• 171011-79-3 (E,4R,5S)-4,6-Dimethyl-5-<(p-methoxybenzyl)oxy>-7-<(1R,3R,4R)-3-methoxy-4-<(triisopropylsilyl)oxy>cyclohexyl>-6-heptan-2-ynyl 1,1,1-trimethylacetate 
• 144401-98-9 (S)-2-(4-methoxybenzyloxy)propionic acid ethyl ester 
• 206272-20-0 allyl 4,6-O-benzylidene-2-deoxy-3-O-(4-methoxyphenylmethyl)-2-(2,2,2-trichloroethoxycarbonylamino)-α-D-glucopyranoside 
• 288852-06-2 methyl (S)-3-(4-methoxyphenyl)methoxy-2-(N-phenylmethoxycarbonyl)aminopropanoate 
• 548464-35-3 4-methoxybenzyl (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl ether 
• 126361-27-1 (S)-(p-methoxybenzyloxy)propanal 
• 218435-12-2 (2R)-2-[(4-methoxybenzyl)oxy]propanal 
• 634891-86-4 (-)-(3S)-[3-(4-methoxybenzyloxy)-non-1-ynyl]trimethylsilane 
• 676548-86-0 [(S)-3-(4-Methoxy-benzyloxy)-hex-5-en-1-ynyl]-trimethyl-silane 
• 623926-33-0 (4R,5S,6S,7S)-1,6-bis(tert-butyldimethylsilanyloxy)-5,7-dimethylnon-8-en-4-yl 4-methoxybenzyl ether 

Relevant articles and documents

Synthesis of a chiral building block for highly functionalized polycyclic ethers

An efficient procedure for preparing enantiopure polycyclic ethers is reported. The protocol is based on the photo-oxidation/conjugate addition sequence over a chiral functionalized furan, which was prepared from commercially available tri-O-acetyl-d-gluc

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Total Synthesis of DHA and DPA n-3Non-Enzymatic Oxylipins

Oxylipins are formed in vivo from polyunsaturated fatty acids (PUFAs). A large structural variety of compounds is grouped under the term oxylipins, which differ from their formation mechanism (involving enzymes or not), as well as their chemical structures (cyclopentane, tetrahydrofuran, hydroxylated-PUFA, etc.). All structures of oxylipins are of great biological interest. Directly correlated to oxidative stress phenomenon, non-enzymatic oxylipins are used as systemic and/or specific biomarkers in various pathologies, and more especially, they were found to have their own biological properties. Produced in vivo as a non-separable mixture of isomers, their total synthesis is a keystone to answer biological questions. In this work, the total synthesis of three non-enzymatic oxylipins derived from docosahexaenoic acid (DHA) and docosapentanoic acid (DPAn-3) is described using a unique and convergent synthetic strategy.

Diastereoselective synthesis of trisubstituted olefins using a silicon-tether ring-closing metathesis strategy

The diastereoselective synthesis of trisubstituted olefins with concomitant C-C bond formation is still a difficult challenge, and olefin metathesis reactions for the formation of such alkenes are usually not high yielding or/and diastereoselective. Herein we report an efficient and diastereoselective synthesis of trisubstituted olefins flanked by an allylic alcohol, by a silicon-tether ring-closing metathesis strategy. Both E- and Z-trisubstituted alkenes were synthesised, depending on the method employed to cleave the silicon tether. Furthermore, this methodology features a novel Peterson olefination for the synthesis of allyldimethylsilanes. These versatile intermediates were also converted into the corresponding allylchlorodimethylsilanes, which are not easily accessible in high yields by other methods.