892489-52-0

Basic information

• Product Name: trans-4-[4-[[[5-[(3,4-Difluorophenyl)amino]-1,3,4-oxadiazol-2-yl]carbonyl]amino]phenyl]cyclohexaneacetic acid
• Synonyms: trans-4-[4-[[[5-[(3,4-Difluorophenyl)amino]-1,3,4-oxadiazol-2-yl]carbonyl]amino]phenyl]cyclohexaneacetic acid;AZD-3988
• CAS NO: 892489-52-0
• Molecular Formula: C₂₃H₂₂F₂N₄O₄
• Molecular Weight: 456.447
• Mol File: 892489-52-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.402
• Refractive Index: 1.627
• PKA: 4.72±0.10(Predicted)
• CAS DataBase Reference: trans-4-[4-[[[5-[(3,4-Difluorophenyl)amino]-1,3,4-oxadiazol-2-yl]carbonyl]amino]phenyl]cyclohexaneacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: trans-4-[4-[[[5-[(3,4-Difluorophenyl)amino]-1,3,4-oxadiazol-2-yl]carbonyl]amino]phenyl]cyclohexaneacetic acid(892489-52-0)
• EPA Substance Registry System: trans-4-[4-[[[5-[(3,4-Difluorophenyl)amino]-1,3,4-oxadiazol-2-yl]carbonyl]amino]phenyl]cyclohexaneacetic acid(892489-52-0)

Safety Data

• Hazardous Substances Data: 892489-52-0(Hazardous Substances Data)

Usage

Description

trans-4-[4-[[[5-[(3,4-Difluorophenyl)amino]-1,3,4-oxadiazol-2-yl]carbonyl]amino]phenyl]cyclohexaneacetic acid, also known as AZD 3988, is a diacylglycerol O-acyltransferase (DGAT) enzyme inhibitor. It is a complex organic compound with a unique molecular structure that has been studied for its potential therapeutic applications in the treatment of diabetes and other metabolic diseases.

Uses

Used in Pharmaceutical Industry:
AZD 3988 is used as a DGAT enzyme inhibitor for the treatment of diabetes and other metabolic diseases. It works by inhibiting the enzyme responsible for the synthesis of triglycerides, which helps to reduce the levels of these lipids in the blood and improve overall metabolic health.
Used in Research Applications:
AZD 3988 is also used as a research tool to study the role of DGAT enzymes in lipid metabolism and their potential as therapeutic targets for the treatment of metabolic disorders. trans-4-[4-[[[5-[(3,4-Difluorophenyl)amino]-1,3,4-oxadiazol-2-yl]carbonyl]amino]phenyl]cyclohexaneacetic acid can help researchers gain a better understanding of the underlying mechanisms of these diseases and identify new approaches for their treatment.

InChI:InChI=1/C23H22F2N4O4/c24-18-10-9-17(12-19(18)25)27-23-29-28-22(33-23)21(32)26-16-7-5-15(6-8-16)14-3-1-13(2-4-14)11-20(30)31/h5-10,12-14H,1-4,11H2,(H,26,32)(H,27,29)(H,30,31)/t13-,14-

Upstream product

• 105640-07-1 4-(4-hydroxyphenyl)cyclohexan-1-one 
• 959861-91-7 C₂₈H₂₉NO₂ 
• 892491-69-9 methyl ({4-[trans-4-(2-methoxy-2-oxoethyl)cyclohexyl]phenyl}amino)(oxo)-acetate 
• 701232-68-0 (trans)-methyl 2-(4-(4-(((trifluoromethyl)sulfonyl)oxy)phenyl)cyclohexyl)acetate 
• 701232-67-9 trans-[4-(4-hydroxyphenyl)cyclohexyl]acetic methyl ester 
• 892491-68-8 trans-[4-(4-aminophenyl)cyclohexyl]acetic acid methyl ester 
• 701232-66-8 [4-(4-hydroxyphenyl)cyclohexylidene]acetic acid methyl ester 
• 892491-67-7 methyl [trans-4-(4-{[hydrazino(oxo)acetyl]amino}phenyl)cyclohexyl]acetate 
• 892489-51-9 methyl (trans-4-{4-[({5-[(3,4-difluorophenyl)amino]-1,3,4-oxadiazol-2-yl}carbonyl)amino]phenyl}cyclohexyl)acetate 

Relevant articles and documents

CRYSTALLINE FORM OF (TRANS-4- [ ( { 5- [ (3, 4 -DI FLUOROPHENYL) AMINO] -1,3, 4-OXADIAZOL-2-YL}CARBONYL) AMINO] PH ENYL } CYCLOHEXYL) ACETIC ACID

Novel crystalline forms of the compound (trans-4- {4-[({5-[(3,4-difluorophenyl)amino]- 1,3,4-oxadiazol-2-yl}carbonyl)amino]phenyl}cyclohexyl)acetic acid are provided, together with processes for the manufacture of such forms, pharmaceutical compositions c