89250-26-0

Basic information

• Product Name: 2-(CHLOROMETHYL)-4-(4-NITROPHENYL)-1,3-THIAZOLE
• Synonyms: Astragalus Polysacharin/Astragalus Root Extract;2-(CHLOROMETHYL)-4-(4-NITROPHENYL)-1,3-THIAZOL;2-(Chloromethyl)-4-(4-nitrophenyl)-1,4-thiazole;2-(CHLOROMETHYL)-4-(4-NITROPHENYL)-1,3-THIAZOLE;Astragalus Polysacharin;2-(Chloromethyl)-4-(4-nitrophenyl)thiazole;Astragalus pulysacharide;thiazole, 2-(chloroMethyl)-4-(4-nitrophenyl)-
• CAS NO: 89250-26-0
• Molecular Formula: C₁₀H₇ClN₂O₂S
• Molecular Weight: 254.69
• EINECS: 2017-001-1
• Product Categories: Plant extracts
• Mol File: 89250-26-0.mol
• Article Data: 1

Chemical Properties

• Melting Point: 154.5 °C
• Boiling Point: 406.2 °C at 760 mmHg
• Flash Point: 199.5 °C
• Appearance: /
• Density: 1.439
• Vapor Pressure: 1.95E-06mmHg at 25°C
• Refractive Index: 1.638
• Storage Temp.: 2-8°C
• PKA: 0.32±0.10(Predicted)
• CAS DataBase Reference: 2-(CHLOROMETHYL)-4-(4-NITROPHENYL)-1,3-THIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(CHLOROMETHYL)-4-(4-NITROPHENYL)-1,3-THIAZOLE(89250-26-0)
• EPA Substance Registry System: 2-(CHLOROMETHYL)-4-(4-NITROPHENYL)-1,3-THIAZOLE(89250-26-0)

Safety Data

• Statements: 34
• Safety Statements: 22-26-36/37/39-45
• Hazardous Substances Data: 89250-26-0(Hazardous Substances Data)

Usage

General Description

2-(Chloromethyl)-4-(4-nitrophenyl)-1,3-thiazole is a chemical compound with a thiazole ring and a chloromethyl and nitrophenyl substituents. It is a yellow crystalline powder that is used in the synthesis of pharmaceuticals and agrochemicals. 2-(CHLOROMETHYL)-4-(4-NITROPHENYL)-1,3-THIAZOLE is primarily used as an intermediate in organic synthesis and can be modified to create a variety of different compounds with useful properties. It is important to handle this chemical with care, as it may be hazardous if not handled properly, and proper safety precautions should be taken when working with it.

InChI:InChI=1/C10H7ClN2O2S/c11-5-10-12-9(6-16-10)7-1-3-8(4-2-7)13(14)15/h1-4,6H,5H2

Upstream product

• 53101-04-5 ethyl 4-(4-nitrophenyl)-1,3-thiazole-2-carboxylate 
• 99-81-0 4-Nitrophenacyl bromide 
• 4414-97-5 2-benzoyloxymethyl-4-(4-nitro-phenyl)-thiazole 
• 4414-98-6 [4-(4-nitro-phenyl)-thiazol-2-yl]-methanol 
• 65385-00-4 2-chloromethyl-4-phenylthiazole 

Downstream Products

• 25021-46-9 4-(4-nitro-phenyl)-2-phenoxymethyl-thiazole 
• 859478-46-9 2-ethoxymethyl-4-(4-nitro-phenyl)-thiazole 
• 125983-38-2 4-(4-Nitro-phenyl)-thiazole-2-carbodithioic acid methyl ester 

Relevant articles and documents

Design, synthesis, and biological evaluation of N,N-disubstituted-4-arylthiazole-2-methylamine derivatives as cholesteryl ester transfer inhibitors

Cholesteryl ester transfer protein (CETP) has been identified as a potential target for cardiovascular disease (CVD) for its important role in the reverse cholesteryl transfer (RCT) process. In our previous work, compound 5 was discovered as a moderate CETP inhibitor. The replacement of the amide linker by heterocyclic aromatics and then a series of N,N-substituted-4-arylthiazole-2-methylamine derivatives were designed by utilizing a conformational restriction strategy. Thirty-six compounds were synthesized and evaluated for their CETP inhibitory activities. Structure-activity relationship studies indicate that electron donor groups substituted ring A, and electron-withdrawing groups at the 4-position of ring B were critical for potency. Among these compounds, compound 30 exhibited excellent CETP inhibitory activity (IC50 = 0.79 ± 0.02 μM) in vitro and showed an acceptable metabolic stability.