89315-61-7Relevant articles and documents
Eco-friendly synthesis of 3-etherified estrones
Zheng, Dong-Qing,Jing, Yu,Zheng, Bing-Ying,Ye, Yun-Fei,Xu, Sheng,Tian, Wei-Sheng,Ma, Hai-Yan,Ding, Kai
, p. 2164 - 2169 (2016/04/09)
The conventional etherification uses toxic or hardly degradable alkylating agents. An eco-friendly tandem etherification/aromatization is presented to prepare estrone 3-secondary ethers from easily available dienone 1. Three marketed 3-etherified estrogen drugs were synthesized with the method from commercial available starting material.