894421-55-7

Basic information

• Product Name: (Z)-ethyl 4-bromo-3-(3-(cyclopentyloxy)-4-methoxyphenyl)but-2-enoate
• Synonyms: (Z)-ethyl 4-bromo-3-(3-(cyclopentyloxy)-4-methoxyphenyl)but-2-enoate
• CAS NO: 894421-55-7
• Molecular Weight: 383.282
• Mol File: 894421-55-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (Z)-ethyl 4-bromo-3-(3-(cyclopentyloxy)-4-methoxyphenyl)but-2-enoate(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-ethyl 4-bromo-3-(3-(cyclopentyloxy)-4-methoxyphenyl)but-2-enoate(894421-55-7)
• EPA Substance Registry System: (Z)-ethyl 4-bromo-3-(3-(cyclopentyloxy)-4-methoxyphenyl)but-2-enoate(894421-55-7)

Safety Data

• Hazardous Substances Data: 894421-55-7(Hazardous Substances Data)

Upstream product

• 159613-21-5 3-cyclopentyloxy-4-methoxyphenylboronic acid 
• 138509-45-2 4-bromo-2-cyclopentyloxyanisole 
• 90-05-1 2-methoxy-phenol 
• 37942-01-1 5-bromo-2-methoxyphenol 
• 66037-04-5 1-acetoxy-5-bromo-2-methoxybenzene 
• 613-70-7 2-methoxyphenyl acetate 
• 137-43-9 Cyclopentyl bromide 
• 894421-52-4 (E)-ethyl 3-(3-(cyclopentyloxy)-4-methoxyphenyl)but-2-enoate 

Downstream Products

• 85416-73-5 (S)-rolipram 
• 85416-75-7 (R)-4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one 
• 894421-61-5 (Z)-ethyl 4-azido-3-(3-(cyclopentyloxy)-4-methoxyphenyl)but-2-enoate 

Relevant articles and documents

Rh-catalyzed asymmetric hydrogenation of γ-phthalimido-substituted α,β-unsaturated carboxylic acid esters: An efficient enantioselective synthesis of β-aryl-γ-amino acids

(Chemical Equation Presented) A series of chiral β-aryl-γ-amino acid ester derivatives were synthesized in high enantioselectivities (93-97% ee) via the Rh-catalyzed asymmetric hydrogenation of γ-phthalimido-α, β-unsaturated carboxylic acid esters using highly modular chiral BoPhoz-type phosphine-aminophosphine ligands. The method has been applied successfully to the synthesis of several chiral pharmaceuticals including (R)-baclofen and (R)-rolipram with high enantioselectivities.