89466-59-1

Basic information

• Product Name: 2-CHLORO-4-METHYL-6-METHYLSULFANYL-PYRIMIDINE
• Synonyms: 2-CHLORO-4-METHYL-6-METHYLSULFANYL-PYRIMIDINE;2-Chloro-4-methylsulfanyl-6-methylpyrimidine;PyriMidine,2-chloro-4-Methyl-6-(Methylthio)-;2-Chloro-4-Methyl-6-(Methylthio)pyriMidine;2-chloro-4-Methylthio-6-methylpyrimidine
• CAS NO: 89466-59-1
• Molecular Formula: C₆H₇ClN₂S
• Molecular Weight: 174.65118
• Mol File: 89466-59-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 120-122 °C
• Boiling Point: 291.9 °C at 760 mmHg
• Flash Point: 130.3 °C
• Appearance: /
• Density: 1.3 g/cm³
• Refractive Index: 1.581
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0.27±0.30(Predicted)
• CAS DataBase Reference: 2-CHLORO-4-METHYL-6-METHYLSULFANYL-PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-4-METHYL-6-METHYLSULFANYL-PYRIMIDINE(89466-59-1)
• EPA Substance Registry System: 2-CHLORO-4-METHYL-6-METHYLSULFANYL-PYRIMIDINE(89466-59-1)

Safety Data

• Hazardous Substances Data: 89466-59-1(Hazardous Substances Data)

Usage

General Description

2-Chloro-4-methyl-6-methylsulfanyl-pyrimidine is a chemical compound with the molecular formula C6H6ClN3S. It is a pyrimidine derivative with a chlorine atom at the 2-position and a methyl and a methylsulfanyl group at the 4- and 6-positions, respectively. 2-CHLORO-4-METHYL-6-METHYLSULFANYL-PYRIMIDINE is used in the synthesis of pharmaceuticals and agrochemicals. It is also employed in biochemical research as a building block for the preparation of various pyrimidine derivatives. Additionally, this compound has been studied for its potential biological activities, including its antimicrobial and anticancer properties.

InChI:InChI=1/C6H7ClN2S/c1-4-3-5(10-2)9-6(7)8-4/h3H,1-2H3

Upstream product

• 16710-11-5 6-methyl-4-(methylsulfanyl)pyrimidin-2(1H)-one 
• 5424-21-5 2,4-dichloro-6-methylpyrimidine 
• 5188-07-8 sodium thiomethoxide 

Relevant articles and documents

INHIBITORS OF RET

Inhibitors of wild-type RET and its resistant mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.

Regioselective 2-Amination of Polychloropyrimidines

The regioselective amination of substituted di- and trichloropyrimidines affording the 2-substituted products is reported. While aryl- and heteroarylamines require the use of a dialkylbiarylphosphine-derived palladium catalyst for high efficiency, more nucleophilic dialkylamines produce 2-aminopyrimidines under noncatalyzed SNAr conditions. The key is the use of 5-trimethylsilyl-2,4-dichloropyrimidine as a surrogate for the parent dichloropyrimidine. For more challenging cases, the 2-chloro-4-thiomethoxy analogues were prepared and exclusively afford the desired 2-aminated-4-thiomethoxypyrimidine products.

HEPATITIS B VIRAL ASSEMBLY EFFECTORS

Novel assembly effector compounds having a therapeutic effect against hepatitis B viral (HBV) infection are disclosed. Assembly effector molecules described herein can lead to defective viral assembly and also may affect other viral activities associated with chronic HBV infection. Also disclosed is a process to synthesize disclosed compounds, method of treatment of HBV by administration of disclosed compounds, and use of these compounds in the manufacture of medicaments against HBV.