895137-81-2

Basic information

• Product Name: Deoxy Fesoterodine
• Synonyms: Deoxy Fesoterodine;2-Methylpropanoic Acid 2-[(1R)-3-[Bis(1-Methylethyl)aMino]-1-phenylpropyl]-4-Methylphenyl Ester;Fesoterodine IMpurity C
• CAS NO: 895137-81-2
• Molecular Formula: C₂₆H₃₇NO₂
• Molecular Weight: 395.57748
• Product Categories: Amines;Aromatics;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 895137-81-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Deoxy Fesoterodine(CAS DataBase Reference)
• NIST Chemistry Reference: Deoxy Fesoterodine(895137-81-2)
• EPA Substance Registry System: Deoxy Fesoterodine(895137-81-2)

Safety Data

• Hazardous Substances Data: 895137-81-2(Hazardous Substances Data)

Upstream product

• 144-55-8 sodium hydrogencarbonate 
• 79-30-1 isobutyryl chloride 
• 124937-51-5 (R)-(+)-tolterodine 

Downstream Products

• 518360-90-2 (3R)-3-[2-(Isobutyryloxy)-5-Methylphenyl)-N,N-Diisopropyl-N-Methyl-3-Phenylpropan-1-Aminium Iodide 

Relevant articles and documents

Fesoterodine Substantially Free of Dehydroxy Impurity

Provided herein is an impurity of fesoterodine, fesoterodine dehydroxy impurity, 2-[(1R)-3-[bis(1-methylethy)amino]-1-phenylpropyl]-4-methylphenyl isobutyrate, and a process for preparing and isolating thereof. Provided further herein is a highly pure fesoterodine or a pharmaceutically acceptable salt thereof substantially free of fesoterodine dehydroxy impurity, process for the preparation thereof, and pharmaceutical compositions comprising highly pure fesoterodine or a pharmaceutically acceptable salt thereof substantially free of dehydroxy impurity. Provided also herein is a pharmaceutical composition comprising solid particles of pure fesoterodine fumarate substantially free of dehydroxy impurity, wherein 90 volume-percent of the particles (D90) have a size of less than about 200 microns.

A process for the preparation of fesoterodine with low impurities content

Disclosed is a process for the preparation of (R)-2-(3-diisopropylamino-1-phenylpropyl)-4-(hydroxymethyl)-phenol isobutyrate (Fesoterodine) or a pharmaceutically acceptable salt thereof having a low content of impurities such as tolterodine and tolterodine isobutyrate.