895917-83-6

Basic information

• Product Name: (S)-methyl 1-(2-amino-4-chloro-5-methylphenylsulfonyl)pyrrolidine-2-carboxylate
• Synonyms: (S)-methyl 1-(2-amino-4-chloro-5-methylphenylsulfonyl)pyrrolidine-2-carboxylate
• CAS NO: 895917-83-6
• Molecular Weight: 332.808
• Mol File: 895917-83-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-methyl 1-(2-amino-4-chloro-5-methylphenylsulfonyl)pyrrolidine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-methyl 1-(2-amino-4-chloro-5-methylphenylsulfonyl)pyrrolidine-2-carboxylate(895917-83-6)
• EPA Substance Registry System: (S)-methyl 1-(2-amino-4-chloro-5-methylphenylsulfonyl)pyrrolidine-2-carboxylate(895917-83-6)

Safety Data

• Hazardous Substances Data: 895917-83-6(Hazardous Substances Data)

Upstream product

• 88-51-7 6-amino-4-chloro-meta-toluenesulfonic acid 
• 104613-64-1 2-amino-4-chloro-5-methyl benzenesulfonyl chloride 
• 2133-40-6 L-proline methyl ester monohydrochloride 

Relevant articles and documents

Discovery of proline sulfonamides as potent and selective hepatitis C virus NS5b polymerase inhibitors. Evidence for a new NS5b polymerase binding site

Through high throughput screening, substituted proline sulfonamide 6 was identified as HCV NS5b RNA-dependent RNA polymerase inhibitor. Optimization of various regions of the lead molecule resulted in compounds that displayed good potency and selectivity.