896743-08-1

Basic information

• Product Name: [(1S)-1-(4-bromo-phenyl)-2,2,2-trifluoro-ethyl]-((1S)-3-methyl-1-triethylsilanyloxymethyl-butyl)-amine
• Synonyms: [(1S)-1-(4-bromo-phenyl)-2,2,2-trifluoro-ethyl]-((1S)-3-methyl-1-triethylsilanyloxymethyl-butyl)-amine
• CAS NO: 896743-08-1
• Molecular Weight: 468.473
• Mol File: 896743-08-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [(1S)-1-(4-bromo-phenyl)-2,2,2-trifluoro-ethyl]-((1S)-3-methyl-1-triethylsilanyloxymethyl-butyl)-amine(CAS DataBase Reference)
• NIST Chemistry Reference: [(1S)-1-(4-bromo-phenyl)-2,2,2-trifluoro-ethyl]-((1S)-3-methyl-1-triethylsilanyloxymethyl-butyl)-amine(896743-08-1)
• EPA Substance Registry System: [(1S)-1-(4-bromo-phenyl)-2,2,2-trifluoro-ethyl]-((1S)-3-methyl-1-triethylsilanyloxymethyl-butyl)-amine(896743-08-1)

Safety Data

• Hazardous Substances Data: 896743-08-1(Hazardous Substances Data)

Upstream product

• 994-30-9 triethylsilyl chloride 
• 896743-07-0 ((S)-3-methyl-1-triethylsilanyloxymethyl-butyl)-[2,2,2-trifluoro-eth-(E)-ylidene]amine 
• 106-37-6 1.4-dibromobenzene 
• 7533-40-6 (S)-2-amino-4-methylpentan-1-ol 
• 896743-06-9 (S)-3-methyl-1-triethylsilanyloxymethyl-butylamine 

Downstream Products

• 603139-12-4 (2S)-4-methyl-2-[(1S)-2,2,2-trifluoro-1-(4'-methanesulfonyl-biphenyl-4-yl)ethylamino]-pentanoic acid cyanomethyl-amide 
• 603142-80-9 (2S)-2-[(1S)-1-(4-bromo-phenyl)-2,2,2-trifluoro-ethylamino]-4-methyl-pentan-1-ol 

Relevant articles and documents

Diastereoselective arylithium addition to an α-trifluoromethyl imine. Practical synthesis of a potent cathepsin K inhibitor

A practical, chromatography-free synthesis of potent cathepsin K inhibitor 1 is described. The addition of 4-bromophenyllithium to an α- trifluoromethylimine derived from commercially available (S)-leucinol was accomplished in a highly diastereoselective