89729-09-9

Basic information

• Product Name: 5.7-Dioxa-6-thia-spiro[2.5]octane-6-oxide
• Synonyms: 5.7-Dioxa-6-thia-spiro[2.5]octane-6-oxide;1,1-Cyclopropyldimethanol cyclic sulphite;1,1-Cyclopropane dimethanol cyclic sulphate
• CAS NO: 89729-09-9
• Molecular Formula: C₅H₈O₃S
• Molecular Weight: 148.18
• Mol File: 89729-09-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 243℃
• Flash Point: 101℃
• Appearance: /
• Density: 1.51
• Refractive Index: 1.495
• CAS DataBase Reference: 5.7-Dioxa-6-thia-spiro[2.5]octane-6-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 5.7-Dioxa-6-thia-spiro[2.5]octane-6-oxide(89729-09-9)
• EPA Substance Registry System: 5.7-Dioxa-6-thia-spiro[2.5]octane-6-oxide(89729-09-9)

Safety Data

• Hazardous Substances Data: 89729-09-9(Hazardous Substances Data)

Usage

Uses

5,7-Dioxa-6-thiaspiro[2.5]octane 6-Oxide is used as a reagent in the synthesis of benzothiazole and thiazole substituted benzyl alcohols as potent LTD4 antagonists.

InChI:InChI=1/C6H8O3/c7-5-8-3-6(1-2-6)4-9-5/h1-4H2

Upstream product

• 39590-81-3 [1-(hydroxymethyl)cyclopropyl]methanol 
• 1559-02-0 diethyl cyclopropane-1,1-dicarboxylate 

Downstream Products

• 153493-52-8 5,7-dioxa-6-thiaspiro[2.5]octane 6,6-dioxide 
• 152922-71-9 1-(hydroxymethyl)cyclopropaneacetonitrile 

Relevant articles and documents

5 - azaspiro [2.4] heptane - 6 - carboxylic acid derivatives of the synthesis method (by machine translation)

The present invention provides a (5S) - 5 - azaspiro [2.4] heptane - 6 - carboxylic acid derivatives of the synthetic method, in order to 1, 1 - cyclopropane dicarboxylic alcohol as the starting material, the reaction with thionyl chloride, is oxidized and get sulfonic acid ester compound, then with glycine methyl ester imine under the action of the tertiary butyl alcohol potassium condensation, again through the system acidic, alkaline methylsulphonyl complete hydrolysis, cyclization, amino protection of the racemic product, finally split to obtain the finished product, the total yield up to 30% or more, the reaction route step is short, reagent used in the security, the operation is simple, of low cost, high yield, suitable for industrial production. (by machine translation)

SPIROPYRROLIDINES AS MDM2 INHIBITORS

Described are spiropyrrolidines (I) useful as inhibitors of MDM2/p53 interactions and provides useful agents for the treatment of diseases like cancer and retinal macular degeneration diseases. The invented compounds herein have the general Further described are pharmaceutical compositions that comprise one or more compounds of the invention, a pharmaceutically acceptable salt or pro-drug and/or a pharmaceutically acceptable carrier or excipient.

Preparation of cyclic sulfites by transesterification of diols and diisopropyl sulfite

Cyclic sulfites of 1,2-, 1,3- and 1,4-diols can be prepared in high yield by acid or base catalyzed transesterification with diisopropyl sulfite.