898783-80-7Relevant articles and documents
Palladium-catalyzed carbonylative coupling of benzyl chlorides with aryl boronic acids in aqueous media
Wu, Xiao-Feng,Neumann, Helfried,Beller, Matthias
, p. 6146 - 6149 (2010)
A novel chemoselective protocol for the carbonylative Suzuki coupling of benzyl chlorides with aryl boronic acids at low pressure of carbon monoxide has been developed. Applying a commercially available palladium acetate/PCy 3 catalyst system in the presence of potassium phosphate as the base and water as the solvent the coupling reactions proceeded smoothly. To demonstrate the general applicability 12 different α-arylated acetophenones have been synthesized in moderate to good yields (41-78%) under mild conditions.