89892-39-7

Basic information

• Product Name: 2-Bromo-4-cyanobenzyl bromide
• Synonyms: 2-Bromo-4-cyanobenzyl bromide;3-broMo-4-(broMoMethyl)benzonitrile;2-Bromo-1-bromomethyl-4-cyanobenzene;NSC 149637
• CAS NO: 89892-39-7
• Molecular Formula: C₈H₅Br₂N
• Molecular Weight: 274.95
• Mol File: 89892-39-7.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 319.3°C at 760 mmHg
• Flash Point: 146.9°C
• Appearance: /
• Density: 1.92
• Vapor Pressure: 0.000341mmHg at 25°C
• Refractive Index: 1.639
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-Bromo-4-cyanobenzyl bromide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-4-cyanobenzyl bromide(89892-39-7)
• EPA Substance Registry System: 2-Bromo-4-cyanobenzyl bromide(89892-39-7)

Safety Data

• RIDADR: 3439
• HazardClass: 6.1
• PackingGroup: Ⅲ
• Hazardous Substances Data: 89892-39-7(Hazardous Substances Data)

Usage

General Description

2-Bromo-4-cyanobenzyl bromide is a chemical compound with the molecular formula C8H5Br2N. It is a brominated aromatic compound with a cyano group and two bromine atoms attached to a benzene ring. This chemical is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is a versatile reagent in organic chemistry, often used in the formation of carbon-carbon, carbon-nitrogen, and carbon-oxygen bonds. It is known for its ability to undergo nucleophilic aromatic substitution reactions and has found applications in the development of new chemical compounds for various industrial and research purposes.

InChI:InChI=1/C8H5Br2N/c9-4-7-2-1-6(5-11)3-8(7)10/h1-3H,4H2

Upstream product

• 7697-26-9 3-bromo-4-methylbenzoic acid 
• 42872-74-2 3-bromo-4-methyl-benzonitrile 

Downstream Products

• 1261679-15-5 C₉H₅BrN₂ 
• 1195621-94-3 1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborole-6-carbaldehyde 
• 947162-60-9 1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborole-6-carbonitrile 
• 1268336-25-9 4-cyano-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acetate 
• 201342-56-5 (2-bromo-4-cyanophenyl)methyl acetate 

Relevant articles and documents

Discovery of benzhydrol-oxaborole derivatives as Streptococcus pneumoniae leucyl-tRNA synthetase inhibitors

Pneumonia caused by bacterium S. pneumoniae is a severe acute respiratory infectious disease with high morbidity and mortality, especially for children and immunity-compromised patients. The emergence of multidrug-resistant S. pneumoniae also presents a c

Cross-coupling strategy for the synthesis of diazocines

Ethylene bridged azobenzenes are novel, promising molecular switches that are thermodynamically more stable in the (Z) than in the (E) configuration, contrary to the linear azobenzene. However, their previous synthetic routes were often not general, and yields were poorly reproducible, and sometimes very low. Here we present a new synthetic strategy that is both versatile and reliable. Starting from widely available 2-bromobenzyl bromides, the designated molecules can be obtained in three simple steps.

A general method for selective recognition of monosaccharides and oligosaccharides in water

Molecular recognition of carbohydrates plays vital roles in biology but has been difficult to achieve with synthetic receptors. Through covalent imprinting of carbohydrates in boroxole-functionalized cross-linked micelles, we prepared nanoparticle receptors for a wide variety of mono- and oligosaccharides. The boroxole functional monomer bound the sugar templates through cis-1,2-diol, cis-3,4-diol, and trans-4,6-diol. The protein-sized nanoparticles showed excellent selectivity for daldohexoses in water with submillimolar binding affinities and completely distinguished the three biologically important hexoses (glucose, mannose, and galactose). Glycosides with nonpolar aglycon showed stronger binding due to enhanced hydrophobic interactions. Oligosaccharides were distinguished on the basis of their monosaccharide building blocks, glycosidic linkages, chain length, as well as additional functional groups that could interact with the nanoparticles.