899822-97-0 Usage
Description
3-Nitro-1-(4-octylphenyl)-propanone is an organic compound that serves as an intermediate in the synthesis of 1-Hydroxy-3-nitrodeamino Fingolimod (H948155), a derivative of Fingolimod (F805000, HCl salt), a novel immune modulator.
Uses
Used in Pharmaceutical Industry:
3-Nitro-1-(4-octylphenyl)-propanone is used as a synthetic intermediate for the production of 1-Hydroxy-3-nitrodeamino Fingolimod (H948155), which is an impurity of Fingolimod (F805000, HCl salt). Fingolimod is a novel immune modulator that has the potential to prolong allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.
Check Digit Verification of cas no
The CAS Registry Mumber 899822-97-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,9,9,8,2 and 2 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 899822-97:
(8*8)+(7*9)+(6*9)+(5*8)+(4*2)+(3*2)+(2*9)+(1*7)=260
260 % 10 = 0
So 899822-97-0 is a valid CAS Registry Number.
899822-97-0Relevant articles and documents
An alternative efficient approach for the synthesis of Fingolimod hydrochloride
Vinigari, Krishna,Jonnada, Krishna,Mohammed, Noorjahan,Kotu, Girija Mangatayaru
, p. 39 - 48 (2019/01/21)
An efficient process for the synthesis of API Fingolimod Hydrochloride is presented. This proposed synthesis involves simple commercially available octanophenone as a starting material. The route is effective involving seven steps to achieve the target, thus reducing the cycle time, and is cost efficient by 50%. It is an immune modulating drug for the treatment of heart failure and arrhythmias.
INTERMEDIATE COMPOUNDS AND PROCESS FOR THE PREPARATION OF FINGOLIMOD
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Page/Page column 23, (2012/05/19)
The present invention relates to processes for the preparation of (2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride (Fingolimod) and pharmaceutically acceptable salts thereof, and intermediates formed in such processes.