90005-62-2

Basic information

• Product Name: 2-pyridin-3-yl-propionic acid
• Synonyms: 2-pyridin-3-yl-propionic acid;2-(pyridin-3-yl)propanoic acid
• CAS NO: 90005-62-2
• Molecular Formula: C8H9NO2
• Molecular Weight: 151.16256
• EINECS: -0
• Mol File: 90005-62-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-pyridin-3-yl-propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-pyridin-3-yl-propionic acid(90005-62-2)
• EPA Substance Registry System: 2-pyridin-3-yl-propionic acid(90005-62-2)

Safety Data

• Hazardous Substances Data: 90005-62-2(Hazardous Substances Data)

Usage

Description

2-pyridin-3-yl-propionic acid, also known as nipecotic acid, is a pyridine derivative that functions as a GABA uptake inhibitor. It is a chemical compound that prevents the reuptake of the neurotransmitter gamma-aminobutyric acid (GABA) from the synaptic cleft, resulting in increased GABA levels in the brain. This mechanism of action suggests potential therapeutic benefits for various neurological disorders.
Used in Pharmaceutical Industry:
2-pyridin-3-yl-propionic acid is used as a therapeutic agent for neurological conditions due to its ability to increase GABA levels in the brain, which can help in the treatment of disorders such as epilepsy and anxiety.
Used in Neuropharmacology Research:
2-pyridin-3-yl-propionic acid is used as a research compound for studying the excitatory and inhibitory balance in the central nervous system, contributing to the development of new treatments for neurological conditions.

Upstream product

• 169253-34-3 ethyl 2-(pyridin-3-yl)propanoate 
• 54401-85-3 pyridin-4-yl-acetic acid ethyl ester 
• 1121-55-7 3-vinylpyridine 
• 201230-82-2 carbon monoxide 

Relevant articles and documents

Pyridineacetamide derivative serving as CDK inhibitor, and preparation method and application thereof

The invention belongs to the technical field of pyridineacetamide derivatives, and particularly relates to a pyridineacetamide derivative serving as a CDK inhibitor and a preparation method and application of the pyridine acetamide derivative. The pyridineacetamide derivative shows excellent CDK9/CDK7 enzyme inhibitory activity, and can be used for preparing drugs used for treating cancers, especially hematologic cancers including acute myeloid leukemia, multiple myeloma, chronic lymphocytic leukemia, follicular lymphoma and the like and solid tumors such as breast cancer, prostate cancer, ovarian cancer, hepatocellular carcinoma, pancreatic cancer, kidney cancer, stomach cancer, colorectal cancer, lung cancer and the like.

Preparation method of organic carboxylic acid

The invention discloses a preparation method of organic carboxylic acid. The preparation method comprises the following steps that catalysts, olefins, water and solvents are added into a reaction container; CO is introduced; heating reaction is performed; after the reaction completion, separation is performed to obtain organic carboxylic acid; the catalysts comprise transition metal catalysts, ligands and catalysis assistants; the catalysis assistants comprise Lewis acid salt. The preparation method has the advantages that the dependency on protonic acid in the prior art is avoided; the Lewisacid salt is used as the catalysis assistant, so that the corrosion of a reaction system on equipment can be effectively prevented; the requirements on equipment are lowered. The preparation method has excellent substrate practicability; the operation steps are simple and fast; the reaction conditions are mild and are easy to control; the raw materials are cheap and can be easily obtained; the product yield and the product purity are high; the preparation method is suitable for large-scale industrial production; the normal/iso ratio of reaction products can be regulated and controlled throughthe catalysis assistants; the defects of regulating and controlling the normal/iso ratio of the reaction products by traditional phosphine ligands are overcome; the reaction progress of the reaction is simplified; the cost is favorably reduced.