900143-78-4Relevant articles and documents
Regioselective synthesis of N-substituted-4-substituted isothiazolidine-1,1-dioxides
Cleator, Ed,Sheen, Faye J.,Bio, Matthew M.,Jos Brands,Davies, Antony J.,Dolling, Ulf-H.
, p. 4245 - 4248 (2006)
A novel and efficient synthesis of a range of racemic and enantioenriched N-substituted-4-substituted isothiazolidine-1,1-dioxides from epoxides and sulfonamides is described. The critical choice of the activating group for the cyclization event is discussed. The application of this methodology to the synthesis of N-substituted-4,5-disubstituted derivatives is also described.