90071-62-8

Basic information

• Product Name: H-D-PRO-OTBU
• Synonyms: D-PROLINE, 1,1-DIMETHYLETHYL ESTER;D-PROLINE-OTBU;D-PROLINE T-BUTYL ESTER;D-PROLINE T-BUTYL ESTER HYDROCHLORIDE;D-PYRROLIDINE-2-CARBOXYLIC ACID T-BUTYL ESTER;D-PYRROLIDINE-2-CARBOXYLIC ACID T-BUTYL ESTER HYDROCHLORIDE;H-D-PRO-OTBU;H-D-PRO-OTBU HCL
• CAS NO: 90071-62-8
• Molecular Formula: C₉H₁₇NO₂
• Molecular Weight: 171.24
• Product Categories: Amino Acids and Derivatives;Amino ester;Amino Acid Derivatives
• Mol File: 90071-62-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 219.2 °C at 760 mmHg
• Flash Point: 86.4 °C
• Appearance: /
• Density: 0.995g/cm³
• Vapor Pressure: 0.121mmHg at 25°C
• Refractive Index: 1.454
• Storage Temp.: -15°C
• PKA: 8.32±0.10(Predicted)
• CAS DataBase Reference: H-D-PRO-OTBU(CAS DataBase Reference)
• NIST Chemistry Reference: H-D-PRO-OTBU(90071-62-8)
• EPA Substance Registry System: H-D-PRO-OTBU(90071-62-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41-51
• Safety Statements: 26-39
• Hazardous Substances Data: 90071-62-8(Hazardous Substances Data)

Usage

Chemical Properties

Oil

Uses

D-Proline tert-Butyl Ester is the tert-Butyl ester of D-proline (P755990) which is used in the synthesis of (R)-(+)-N-Boc-Pipecolic Acid, (S)-(-)-Coniine, (S)-(+)-Pelletierine, (+)-.beta.-Conhydrine, and (S)-(-)-Ropivacaine and formal synthesis of (-)-Lasubine II and (+)-Cermizine C.

InChI:InChI=1/C9H17NO2/c1-9(2,3)12-8(11)7-5-4-6-10-7/h7,10H,4-6H2,1-3H3/t7-/m1/s1

Upstream product

• 1416352-40-3 (R)-tert-butyl 4-(1,3-dioxolan-2-yl)-2-(diphenylmethyleneamino)butanoate 
• 201206-00-0 Z-D-Pro-OtBu 
• 344-25-2 D-Prolin 

Downstream Products

• 887277-64-7 cyclo(-L-Ae₉-Aib-L-Phe-D-Pro-) 
• 887277-65-8 cyclo(-L-Ae₉(epo)-Aib-L-Phe-D-Pro-) 
• 887277-60-3 Boc-L-Ae₉-Aib-L-Phe-D-Pro-OtBu 
• 1000593-27-0 cyclo(-L-7-bromo-Ahp-Aib-L-Phe-D-Pro-) 
• 291312-78-2 H-L-Asu(OBzl)-Aib-L-Phe-D-Pro-OH TFA salt 
• 1011725-65-7 scyclo [L-2-amino-8-oxoundecanoyl-aminoisobutyryl-L-phenylalanyl-D-prolyl] 
• 139059-75-9 c 
• 162757-03-1 BocLys(Z)-Aib-Phe-(D)ProOtBu 
• 1438257-70-5 cyclo(L-Am₇(SAc)-Aib-L-Phe(p-Cl)-D-Pro) 
• 1438257-69-2 cyclo(L-Am₇(SAc)-Aib-L-Phe(m-Cl)-D-Pro) 
• 1438257-68-1 cyclo(L-Am₇(SAc)-Aib-L-Phe(o-Cl)-D-Pro) 
• 1589545-93-6 cyclo(L-Asu(NHOH)-L-A₃mc6c-L-Phe-D-Pro) 

Relevant articles and documents

Stereoselective synthesis of cyclic amino acids via asymmetric phase-transfer catalytic alkylation

An asymmetric synthesis of cyclic amino acids having piperidine and azepane core structures was realized starting from readily available glycine and alanine esters by combination of phase-transfer catalyzed asymmetric alkylation and subsequent reductive a

D-proline derivatives

New compounds have the formula: wherein R, R1, X and Y have the meanings described herein. Methods are set forth for synthesizing these compounds and using these compounds to treat diseases associated with amyloidosis, such as Alzheimer's disease, maturity onset diabetes mellitus, familial amyloid polyneuropathy, scrapie, and Kreuzfeld-Jacob disease.