9014-81-7

Basic information

• Product Name: FETUIN
• Synonyms: FETUIN I BOVINE;FETUIN;FETUIN, BOVINE;FETUIN, FETAL BOVINE SERUM;fetuins;FETUIN FROM FETAL CALF SERUM*GAMMA-IRRAD IATED CELL;FETUIN FROM FETAL BOVINE SERUM CELL*CULT URE TESTED;Fetuin,Lyophilised
• CAS NO: 9014-81-7
• Molecular Formula: NULL
• Molecular Weight: 0
• EINECS: 232-762-7
• Product Categories: Cell Culture;Miscellaneous Reagents and Supplements;Reagents and Supplements;FetuinApplication Index;Plasma&Blood Proteins;Plasma, Blood, and Related Proteins and Reagents;Serum Proteins;Serum Proteins and Related Enzymes;Miscellaneous Plasma Proteins;Albumins and Transport Proteins;FetuinGlycobiology;GlycoproteinsApplication Index;Control Proteins for Glycosylation Studies;proteins
• Mol File: 9014-81-7.mol
• Article Data: 0

Chemical Properties

• Appearance: /powder
• Storage Temp.: 2-8°C
• Solubility: H2O: 1 mg/mL
• Water Solubility: Soluble in water 1 mg/mL.
• CAS DataBase Reference: FETUIN(CAS DataBase Reference)
• NIST Chemistry Reference: FETUIN(9014-81-7)
• EPA Substance Registry System: FETUIN(9014-81-7)

Safety Data

• WGK Germany: 3
• F: 3-10
• Hazardous Substances Data: 9014-81-7(Hazardous Substances Data)

Usage

Chemical Properties

Serum in sodium acetate buffer

Uses

Fetuin is a protein with the ability to bind to the insulin receptor and inhibit insulin action. Fetuin has been used in studies of type 2 diabetes mellitus (T2DM). In patients with T2DM, fetuin has been shown to be significantly lower when compared to control patients. Fetuin has also been used in studies to demonstrate its protective role in the development of arterial calcification.

General Description

Fetuin from fetal bovine serum is a 64 kDa plasma glycoprotein. It is produced by the liver and adipose tissue.

Biochem/physiol Actions

Fetuin, an inhibitor of insulin receptor tyrosine kinase, modulates bone remodeling and calcium metabolism. It is involved in keratinocytes migration and breast tumor cell proliferative signaling. Fetuin also regulates vascular calcification, insulin resistance and protease activity It acts as a biomarker for neurodegenerative diseases. Fetuin has anti-inflammatory property.