90149-90-9

Basic information

• Product Name: 1,4-Naphthalenedione, 2-hydroxy-3-(3-phenyl-2-propenyl)-
• CAS NO: 90149-90-9
• Molecular Formula: C19H14O3
• Molecular Weight: 290.318
• Mol File: 90149-90-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,4-Naphthalenedione, 2-hydroxy-3-(3-phenyl-2-propenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Naphthalenedione, 2-hydroxy-3-(3-phenyl-2-propenyl)-(90149-90-9)
• EPA Substance Registry System: 1,4-Naphthalenedione, 2-hydroxy-3-(3-phenyl-2-propenyl)-(90149-90-9)

Safety Data

• Hazardous Substances Data: 90149-90-9(Hazardous Substances Data)

Upstream product

• 83-72-7 2-hydroxynaphtho-1,4-quinone 
• 4392-24-9 Cinnamyl bromide 
• 36417-25-1 2-hydroxy-1,4-naphthoquinone silver salt 
• 2687-12-9 cinnamyl chloride 
• 4392-24-9 3-bromo-1-phenyl-1-propenyl bromide 
• 4407-36-7 (2E)-3-phenyl-2-propen-1-ol 
• 4393-06-0 1-Phenyl-2-propen-1-ol 

Downstream Products

• 90149-96-5 2-phenyl-3,4-dihydro-2H-benzo[h]chromene-5,6-dione 

Relevant articles and documents

PHARMACEUTICAL COMPOSITION FOR THE TREATMENT AND PREVENTION OF DISEASES INVOLVING IMPOTENCE

Disclosed is a pharmaceutical composition for the treatment and/or prevention of erectile dysfunction, comprising (a) a therapeutically effective amount of a compound represented by Formula 1 or 2, and (b) a pharmaceutically acceptable carrier, a diluent or an excipient, or any combination thereof.

β-Lapachone: Synthesis of Derivatives and Activities in Tumor Models

In order to find a 3,4-dihydro-2H-naphthopyran-5,6-dione more potent than the naturally occurring 2,2-dimethyl derivative , we synthesized a series of analogous compounds with modifications at position 2 of the pyran ring or at positions 8 and 9 of the benzene ring.Of the compounds tested in vitro for inhibition of RNA-dependent DNA polymerase and in mice infected with Rauscher leukemia, all retained good enzyme activity.Inhibition of the reverse transcriptase activity of the 2,2-substituted derivatives 10b-e was as strong as 10a.However, only the 2-methyl-2-phenyl derivative 10e proved to be about as potent as 2,2-dimethyl reference compound 10a in prolonging the mean survival time of mice with Rauscher leukemia virus induced leukemia.