901765-36-4Relevant articles and documents
Efficient and highly stereoselective assembly of rosuvastatin
?terk, Damjan,Zaugg, Werner,Beutler, Ulrich,Loeser, Eric M.,Prasad, Kapa,?asar, Zdenko
, p. 1338 - 1341 (2018/03/29)
We report an asymmetric synthesis of rosuvastatin starting from an α,β-unsaturated aldehyde precursor containing the rosuvastatin heterocyclic core at its terminus. The α,β-unsaturated carbonyl starting material was used in a highly stereoselective Ti-catalyzed aldol condensation followed by a syn-selective Narasaka–Prasad borane-ketone reduction and hydrolysis step to provide rosuvastatin calcium. This approach provides concise access to stereochemically pure rosuvastatin from simple and readily available starting materials in 3 steps. The overall three-step process provides rosuvastatin calcium in 80% yield, >99:1 syn/anti ratio, and >99% ee.
PROCESS FOR THE PREPARATION OF ROSUVASTATIN
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Page/Page column 27, (2008/12/06)
A process for the manufacture of a compound of formula (V), useful for making rosuvastatin, by a stereoselective aldol reaction is described.