90221-55-9

Basic information

• Product Name: 2-bromo-5-methylbenzaldehyde
• Synonyms: 2-bromo-5-methylbenzaldehyde;2-BroMo-5-Methylbenzaldehyde, 95+%;Bromo-5-methylbenzaldehyde
• CAS NO: 90221-55-9
• Molecular Formula: C₈H₇BrO
• Molecular Weight: 199.046
• Mol File: 90221-55-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 43 °C
• Boiling Point: 253.2±20.0℃ (760 Torr)
• Flash Point: 89.5±9.1℃
• Appearance: /
• Density: 1.490±0.06 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: soluble in Methanol
• CAS DataBase Reference: 2-bromo-5-methylbenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-5-methylbenzaldehyde(90221-55-9)
• EPA Substance Registry System: 2-bromo-5-methylbenzaldehyde(90221-55-9)

Safety Data

• Hazardous Substances Data: 90221-55-9(Hazardous Substances Data)

Usage

Chemical Properties

Pale yellow powder

Upstream product

• 959687-83-3 2-bromo-5-methyl-1-(methoxymethoxymethyl)benzene 
• 870-63-3 prenyl bromide 
• 1048108-06-0 2-bromo-N-methoxy-N,5-dimethylbenzamide 
• 42872-83-3 2-bromo-5-methylbenzylnitrile 
• 620-22-4 3-Methylbenzonitrile 
• 727985-37-7 ?(2-bromo-5-methylphenyl)methanol 
• 6967-82-4 2-bromo-5-methylbenzoic acid 

Downstream Products

• 90772-52-4 4-Brom-7-methyl-indanon-(1) 
• 1312922-88-5 5-methyl-1-phenyl-2-(phenylethynyl)-1H-indole 
• 1308314-83-1 (+)-(1S,3'R,4'S_.6'R)-6'-(2-(tert-butyldiphenylsilyloxy)ethyl)-6-methyl-4'-(triisopropylsilyloxy)-3',4',5',6'-tetrahydrospiro[isochroman-1,2'-pyran]-3'-ol 
• 1308314-62-6 (+)-(1R,3'R,4'S_.6'R)-6'-(2-(tert-butyldiphenylsilyloxy)ethyl)-6-methyl-4'-(triisopropylsilyloxy)-3',4',5',6'-tetrahydrospiro[isochroman-1,2'-pyran]-3'-ol 
• 1308314-84-2 (+)-(1S,3'R,4'S_.6'R)-6'-(2-(tert-butyldiphenylsilyloxy)ethyl)-7-methyl-4'-(triisopropylsilyloxy)-3',4',5',6'-tetrahydro-3H-spiro[benzo[c]oxepine-1,2'-pyran]-3'-ol 
• 1308314-46-6 (-)-2-(2-(2-((2R,4S)-2-(tert-butyldiphenylsilyloxy)ethyl)-4-(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl)-5-methylphenyl)ethanol 
• 1308314-55-7 (-)-3-(2-((2R,4S)-2-(2-(tert-butyldiphenylsilyloxy)ethyl)-4-(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl)-5-methylphenyl)propan-1-ol 
• 1195212-99-7 C₉H₁₁BrO 
• 1261751-19-2 ethyl 3-(2-bromo-5-methylphenyl)propanoate 
• 727985-37-7 ?(2-bromo-5-methylphenyl)methanol 

Relevant articles and documents

AuCl3-Catalyzed Ring-Closing Carbonyl–Olefin Metathesis

Compared with the ripeness of olefin metathesis, exploration of the construction of carbon–carbon double bonds through the catalytic carbonyl–olefin metathesis reaction remains stagnant and has received scant attention. Herein, a highly efficient AuCl3-catalyzed intramolecular ring-closing carbonyl–olefin metathesis reaction is described. This method features easily accessible starting materials, simple operation, good functional-group tolerance and short reaction times, and provides the target cyclopentenes, polycycles, benzocarbocycles, and N-heterocycle derivatives in good to excellent yields.

Intriguing substituent effect in modified Hoveyda-Grubbs metathesis catalysts incorporating a chelating iodo-benzylidene ligand

A series of modified Hoveyda-Grubbs catalysts incorporating a chelating iodo-benzylidene ligand were prepared and characterized. The presence of electron-withdrawing ring substituents in the para position to the iodide was found to decrease the catalytic activity, revealing that dissociation of the Ru...I-Ar bond is not the rate-determining step.

DIAMINOPROPANE DERIVED MACROCYCLES AS INHIBITORS OF BETA AMYLOID PRODUCTION

There is provided a series of macrocyclic diaminopropanes of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, m, n, W, X, Y, Z and L as defined herein, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein (APP) by β-secretase and, more specifically, inhibit the production of Aβ-peptide. The present disclosure is directed to compounds useful in the treatment of neurological disorders related to β-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity.