90280-15-2Relevant articles and documents
A daily single dose of a novel modafinil analogue CE-123 improves memory acquisition and memory retrieval
Kristofova, Martina,Aher, Yogesh D.,Ilic, Marija,Radoman, Bojana,Kalaba, Predrag,Dragacevic, Vladimir,Aher, Nilima Y.,Leban, Johann,Korz, Volker,Zanon, Lisa,Neuhaus, Winfried,Wieder, Marcus,Langer, Thierry,Urban, Ernst,Sitte, Harald H.,Hoeger, Harald,Lubec, Gert,Aradska, Jana
, p. 83 - 94 (2018)
Dopamine reuptake inhibitors have been shown to improve cognitive parameters in various tasks and animal models. We recently reported a series of modafinil analogues, of which the most promising, 5-((benzhydrylsulfinyl)methyl) thiazole (CE-123), was selec
Heterocyclic Analogues of Modafinil as Novel, Atypical Dopamine Transporter Inhibitors
Kalaba, Predrag,Aher, Nilima Y.,Ili?, Marija,Draga?evi?, Vladimir,Wieder, Marcus,Miklosi, Andras G.,Zehl, Martin,Wackerlig, Judith,Roller, Alexander,Beryozkina, Tetyana,Radoman, Bojana,Saroja, Sivaprakasam R.,Lindner, Wolfgang,Gonzalez, Eduardo Perez,Bakulev, Vasiliy,Leban, Johann Jakob,Sitte, Harald H.,Urban, Ernst,Langer, Thierry,Lubec, Gert
, p. 9330 - 9348 (2017)
Modafinil is a wake promoting compound with high potential for cognitive enhancement. It is targeting the dopamine transporter (DAT) with moderate selectivity, thereby leading to reuptake inhibition and increased dopamine levels in the synaptic cleft. A s
A novel heterocyclic compound improves working memory in the radial arm maze and modulates the dopamine receptor D1R in frontal cortex of the Sprague-Dawley rat
Hussein, Ahmed M.,Aher, Yogesh D.,Kalaba, Predrag,Aher, Nilima Y.,Draga?evi?, Vladimir,Radoman, Bojana,Ili?, Marija,Leban, Johann,Beryozkina, Tetyana,Ahmed, Abdel Baset M.A.,Urban, Ernst,Langer, Thierry,Lubec, Gert
, p. 308 - 315 (2017/06/27)
A series of compounds have been shown to enhance cognitive function via the dopaminergic system and indeed the search for more active and less toxic compounds is continuing. It was therefore the aim of the study to synthetise and test a novel heterocyclic