90322-71-7 Usage
General Description
2-Carboxy-6-nitrobenzeneacetic acid, also known as "Carboxynitrobenzene", is a chemical compound used in the synthesis of pharmaceuticals and agrochemicals. It is a yellow crystalline substance with a molecular formula of C9H7NO6 and a molecular weight of 225.16 g/mol. 2-Carboxy-6-nitrobenzeneacetic acid is known for its anti-inflammatory and analgesic properties and is used in the manufacturing of non-steroidal anti-inflammatory drugs (NSAIDs) such as diclofenac. 2-Carboxy-6-nitrobenzeneacetic acid is also used as an intermediate in the production of dyes, pigments, and other specialty chemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 90322-71-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,0,3,2 and 2 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 90322-71:
(7*9)+(6*0)+(5*3)+(4*2)+(3*2)+(2*7)+(1*1)=107
107 % 10 = 7
So 90322-71-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H9NO6/c1-2-17-10(14)8-6(9(12)13)4-3-5-7(8)11(15)16/h3-5H,2H2,1H3,(H,12,13)
90322-71-7Relevant articles and documents
Identification of novel PARP-1 inhibitors: Drug design, synthesis and biological evaluation
Xie, Zhouling,Zhou, Youli,Zhao, Wei,Jiao, He,Chen, Yu,Yang, Yong,Li, Zhiyu
supporting information, p. 4557 - 4561 (2015/10/12)
A series of AG014699 derivatives containing a novel scaffold of 2,3-dihydro-1H-[1,2]diazepino[4,5,6-cd]indole-1,4(6H)-dione were synthesized and evaluated for their inhibitory activities toward PARP-1 enzyme and two cell lines, MCF-7 cells and the BRCA1-deficient MDA-MB-436 cells. Our results demonstrated that of all AG014699 derivatives synthesized in this work, compounds 6 and 7 showed strong PARP-1 inhibitory activity (IC50 = 3.5 nM and 2.4 nM, respectively), only four and three times less potent than AG014699. Compound 6 also had significantly cell inhibitory activity against both MCF-7 cells (CC50 = 25.8 μM) and the BRCA1-deficient MDA-MB-436 cells (CC50 = 5.4 μM), nearly as good as AG014699, indicating that it can be a promising compound for further evaluation.
