908591-25-3

Basic information

• Product Name: 2-Isopropyl-4-[(N-methylamino)methyl]thiazole hydrochloride
• Synonyms: 2-Isopropyl-4-[(N-methylamino)methyl]thiazole hydrochloride;2-Isopropyl-4(((N-Methyl)aMino)Methyl)thiazole HCl;2-Isopropyl-4-[(N-Me;2-Isopropyl-4-(MethylaMinoMethyl)thiazoledihydrochloride;N-Methyl-2-(1-Methylethyl)-4-thiazoleMethanaMine Hydrochloride;1-(2-Isopropylthiazol-4-yl)-N-MethylMethanaMine hydrochloride;4-Thiazolemethanamine, N-methyl-2-(1-methylethyl)-, hydrochloride (1:1);2_lsopropyl-4-[(N-methylamino)methyllthiazole hydrochloride(Ritonavir)
• CAS NO: 908591-25-3
• Molecular Formula: C₈H₁₄N₂S*ClH
• Molecular Weight: 206.74
• EINECS: 1312995-182-4
• Product Categories: API intermediates;Heterocycles;Intermediates
• Mol File: 908591-25-3.mol
• Article Data: 1

Chemical Properties

• Melting Point: 62-65°C
• Boiling Point: 230.9°C at 760 mmHg
• Flash Point: 93.4°C
• Appearance: /
• Vapor Pressure: 0.0643mmHg at 25°C
• Storage Temp.: Hygroscopic, Refrigerator, Under Inert Atmosphere
• CAS DataBase Reference: 2-Isopropyl-4-[(N-methylamino)methyl]thiazole hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Isopropyl-4-[(N-methylamino)methyl]thiazole hydrochloride(908591-25-3)
• EPA Substance Registry System: 2-Isopropyl-4-[(N-methylamino)methyl]thiazole hydrochloride(908591-25-3)

Safety Data

• Hazardous Substances Data: 908591-25-3(Hazardous Substances Data)

Usage

Uses

Intermediate for Ritonavir, a kind of anti-AIDS pharmaceutical

InChI:InChI=1/C8H14N2S.ClH/c1-6(2)8-10-7(4-9-3)5-11-8;/h5-6,9H,4H2,1-3H3;1H

Synthetic route

N-methyl-N-<(2-isopropyl-4-thiazolyl)methyl>amine (154212-60-9) → 2-isopropyl-4-(((N-methyl)amino)methyl)thiazole hydrochloride (908591-25-3)

Conditions	Yield
With hydrogenchloride In water; isopropyl alcohol at 60℃; for 1h;

2-isopropyl-4-(((N-methyl)amino)methyl)thiazole hydrochloride (908591-25-3) + N-<<(4-nitrophenyl)oxy>carbonyl>-L-valine methyl ester (162537-10-2) → N-((N-methyl-N-((2-isopropyl-4-thiazolyl)methyl)amino)carbonyl)-L-valine methyl ester (154248-99-4)

Conditions	Yield
With dmap; triethylamine In tetrahydrofuran at 70℃; for 8h;

Upstream product

• 154212-60-9 N-methyl-N-<(2-isopropyl-4-thiazolyl)methyl>amine 

Downstream Products

• 154248-99-4 N-((N-methyl-N-((2-isopropyl-4-thiazolyl)methyl)amino)carbonyl)-L-valine methyl ester 

Relevant articles and documents

ACID ADDITION SALT OF 2-ISOPROPYL-4-(((N-METHYL)AMINO)METHYL)THIAZOLE AND ITS?USE IN THE PREPARATION OF RITONAVIR

The present invention relates to a novel acid addition salt of 2-Isopropyl-4-(((N-methyl)amino)methyl)thiazole of Formula (I) which is a useful intermediate for preparing HIV protease inhibitors. The present invention further provides a process for preparing ritonavir, a HIV protease inhibitor, using the compound of Formula (I).