9087-69-8

Basic information

• Product Name: HAPTOGLOBIN, HUMAN
• Synonyms: HAPTOGLOBIN, MIXED TYPE, HUMAN;HAPTOGLOBIN, MIXED TYPE, HUMAN PLASMA;HAPTOGLOBIN (PLASMA/MIXED TYPE);HAPTOGLOBULIN HUMAN;haptoglobins;haptoglobin from human plasma;Haptoglobin from pooled human plasma;Recombinant Human Haptoglobin
• CAS NO: 9087-69-8
• Molecular Formula: NULL
• Molecular Weight: 0
• Product Categories: Haptoglobin;HaptoglobinImmune Cell Signaling and Blood;Proteins of Inflammation;Immune System Regulation;Plasma&Blood Proteins;Plasma, Blood, and Related Proteins and Reagents;proteins
• Mol File: 9087-69-8.mol
• Article Data: 0

Chemical Properties

• Appearance: off-white/powder
• Storage Temp.: 2-8°C
• Solubility: H2O: 10 mg/mL, clear to faintly turbid, colorless to almost
• CAS DataBase Reference: HAPTOGLOBIN, HUMAN(CAS DataBase Reference)
• NIST Chemistry Reference: HAPTOGLOBIN, HUMAN(9087-69-8)
• EPA Substance Registry System: HAPTOGLOBIN, HUMAN(9087-69-8)

Safety Data

• Hazard Codes: B
• WGK Germany: 3
• RTECS: MG8575500
• Hazardous Substances Data: 9087-69-8(Hazardous Substances Data)

Usage

Description

Haptoglobin, also known as HAPTOGLOBIN, HUMAN, is an α2-globulin found in normal plasma with a concentration range of 82-236 mg/dl, accounting for 0.4-2.6% of the total plasma proteins. It is an acute phase plasma protein with a monomeric form consisting of four polypeptide chains: two α chains and two β chains. Haptoglobin plays a crucial role in binding free hemoglobin and preventing hemoglobin-induced oxidative damage.

Uses

Used in Reproductive Biology Research:
HAPTOGLOBIN, HUMAN is used as a research tool for studying the induction of the acrosome reaction in sperm. The acrosome reaction is a critical process in fertilization, and understanding its regulation can provide insights into male fertility and reproductive health.
Used in Cryopreservation Studies:
HAPTOGLOBIN, HUMAN is used as a cryoprotective agent in the study of sperm cryopreservation. Exposure to low temperatures increases the rate of sperm fusion with zona-free hamster oocytes, which can help improve the success rates of assisted reproductive techniques.
Used in Hemoglobin Binding and Oxidative Stress Research:
HAPTOGLOBIN, HUMAN is used as a hemoglobin-binding protein in research focused on the prevention of hemoglobin-induced oxidative damage. By binding to free hemoglobin, Haptoglobin helps protect cells and tissues from oxidative stress and inflammation.
Used in Acute Phase Protein Studies:
HAPTOGLOBIN, HUMAN is used as an acute phase protein in research related to inflammation, infection, and tissue damage. Its role in the acute phase response can provide valuable information on the body's immune response and the development of potential therapeutic interventions.
Used in Clinical Diagnostics:
HAPTOGLOBIN, HUMAN is used as a biomarker in clinical diagnostics to assess various conditions, including inflammation, hemolytic anemia, and liver disease. Measuring Haptoglobin levels can help in the diagnosis, monitoring, and management of these conditions.
Used in Drug Development:
HAPTOGLOBIN, HUMAN is used as a target for drug development in the pharmaceutical industry. Understanding the structure and function of Haptoglobin can aid in the design of new drugs targeting its binding and protective properties, potentially leading to novel therapeutic agents for various diseases.

Biochem/physiol Actions

Functions by binding to plasma hemoglobin (from hemolysis). The complex is removed from the circulation, by binding to CD163 receptors on macrophages, to salvage iron and prevent oxidative damage.