90870-83-0

Basic information

• Product Name: 4-(4-MORPHOLINYL)-1H-PYRROLO[2,3-D]PYRIMIDINE
• Synonyms: 4-(4-MORPHOLINYL)-1H-PYRROLO[2,3-D]PYRIMIDINE;4-{7H-Pyrrolo[2,3-d]pyrimidin-4-yl}morpholine;4-morpholino-7H-pyrrolo[2,3-d]pyrimidine;4-(1H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)MORPHOLINE
• CAS NO: 90870-83-0
• Molecular Formula: C10H12N4O
• Molecular Weight: 204.23
• Mol File: 90870-83-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 436.176°C at 760 mmHg
• Flash Point: 217.592°C
• Appearance: /
• Density: 1.347g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.668
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-(4-MORPHOLINYL)-1H-PYRROLO[2,3-D]PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-MORPHOLINYL)-1H-PYRROLO[2,3-D]PYRIMIDINE(90870-83-0)
• EPA Substance Registry System: 4-(4-MORPHOLINYL)-1H-PYRROLO[2,3-D]PYRIMIDINE(90870-83-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 90870-83-0(Hazardous Substances Data)

Usage

General Description

4-(4-Morpholinyl)-1H-pyrrolo[2,3-d]pyrimidine is a chemical compound with potential pharmaceutical applications. It is a heterocyclic compound containing a pyrrolopyrimidine ring system and a morpholine group. The compound has been studied for its potential in inhibiting the growth of cancer cells by targeting specific enzymes and pathways involved in tumor development. It may have potential as a therapeutic agent for treating certain types of cancer and other diseases. Further research is needed to fully understand the biological activities and potential applications of this compound.

InChI:InChI=1/C10H12N4O/c1-2-11-9-8(1)10(13-7-12-9)14-3-5-15-6-4-14/h1-2,7H,3-6H2,(H,11,12,13)

Upstream product

• 110-91-8 morpholine 
• 3680-69-1 4-chloro-1H-pyrrolo[2,3-d]pyrimidine 

Relevant articles and documents

A microwave-assisted synthetic approach to analyzing disubstituted pyrrolo[2,3-d]pyrimidine diversity via ligand-free Cu-catalyzed N-arylation

Facile introduction of diverse substituents to 2- or 4-chloro-7H-pyrrolo[2,3-d]pyrimidines was examined with microwave-assisted nucleophilic substitution and Cu-catalyzed N-arylation. Microwave-assisted Cu-catalyzed N-arylation of pyrrolo[2,3-d]pyrimidines with various nucleophiles proceeded very well with diverse heteroaryl halides. Sequential microwave-assisted substitution provided good to excellent yields of 2,7- or 4,7-disubstituted pyrrolo[2,3-d]pyrimidines, with short reaction times and energy savings compared with conventional thermal heating. The diverse pyrrolo[2,3-d]pyrimidine derivatives are useful for screening drug candidates for various diseases.

NOVEL HETEROCYCLIC COMPOUNDS AS METAP-2 INHIBITORS

Compounds of the formula I, in which D, X, Y, Z, R and R1 have the meanings indicated in Claim 1, are inhibitors of methionine aminopeptidase and can be employed for the treatment of tumours.

Monocyclic-7H-pyrrolo[2,3-d]pyrimidine compounds, compositions, and methods of use

Novel pyrrolo[2,3-d]pyrimidine compounds useful as inhibitors of the enzyme protein tyrosine kinases such as Janus Kinase 3 as well as immunosuppressive agents for organ transplants, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, Leukemia and other autoimmune diseases are described.