908852-19-7

Basic information

• Product Name: Atorvastatin MethanaMine Salt
• Synonyms: Atorvastatin MethanaMine Salt;Methanamine (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl;Methanamine (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1;Methanamine (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate
• CAS NO: 908852-19-7
• Molecular Formula: CH₅N*C₃₃H₃₅FN₂O₅
• Molecular Weight: 589.6969032
• Mol File: 908852-19-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Atorvastatin MethanaMine Salt(CAS DataBase Reference)
• NIST Chemistry Reference: Atorvastatin MethanaMine Salt(908852-19-7)
• EPA Substance Registry System: Atorvastatin MethanaMine Salt(908852-19-7)

Safety Data

• Hazardous Substances Data: 908852-19-7(Hazardous Substances Data)

Usage

General Description

Atorvastatin methanamine salt is a chemical compound that combines atorvastatin, a medication used to lower cholesterol and reduce the risk of heart disease, with methanamine, a compound used as a stabilizing agent. Atorvastatin works by inhibiting an enzyme in the liver that plays a key role in the production of cholesterol, while methanamine helps to stabilize the compound for use as a medication. This combination allows for better stability and effectiveness of atorvastatin when used as a medication, ultimately aiding in the treatment and prevention of cardiovascular diseases.

InChI:InChI=1/C33H35FN2O5.C33H34FN2O5.CH5N.Ca/c2*1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40;1-2;/h3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40);3-16,21,26-27,37H,17-20H2,1-2H3,(H,35,41)(H,39,40);2H2,1H3;/q;-1;;+2/p-1/t2*26-,27-;;/m11../s1

Upstream product

• 74-89-5 methylamine 

Relevant articles and documents

Process for producing atorvastatin hemicalcium

A process is provided for preparing pharmaceutical grade atorvastatin hemicalcium salt comprising: (a) deesterifying, wherein R is an ester protecting group to (b) extracting R(R*,R*)-3 into an organic solvent or mixture of solvents, (c) adding a base of formula NR1R2R3 wherein R1, R2 and R3 are independently selected from H, substituted or non-substituted C1 to C7 alkyl, C6 to C9 aryl, C8 to C10 aralkyl or aminoalkyl to form atorvastatin base salt, (d) isolating by precipitation of the above atorvastatin base salt and purifying when necessary,