909-13-7

Basic information

• Product Name: dihydrocostatolide
• Synonyms: dihydrocostatolide
• CAS NO: 909-13-7
• Molecular Formula: C22H28O5
• Molecular Weight: 372.45472
• Mol File: 909-13-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 509°Cat760mmHg
• Flash Point: 173.8°C
• Appearance: /
• Density: 1.162g/cm³
• CAS DataBase Reference: dihydrocostatolide(CAS DataBase Reference)
• NIST Chemistry Reference: dihydrocostatolide(909-13-7)
• EPA Substance Registry System: dihydrocostatolide(909-13-7)

Safety Data

• Hazardous Substances Data: 909-13-7(Hazardous Substances Data)

Upstream product

• 909-14-8 (-)-calanolide B 
• 183904-54-3 (10S,11S)-10,11-dihydro-4-propyl-6,6,10,11-tetramethyl-2H,6H,12H-benzo[1,2-b;3,4-b';5,6-b'']tripyran-2,12-dione 
• 161753-49-7 (+/-)-12-oxocalanolide A 

Relevant articles and documents

Structure-activity modifications of the HIV-1 inhibitors (+)-calanolide A and (-)-calanolide B

The Δ7,8 olefinic linkages within (+)-calanolide A (1) and (-)- calanolide B (2) were catalytically reduced to determine impact on the anti- HIV activity of the parent compounds. In addition, a series of structure modifications of the C-12 hydroxyl group in (-)-calanolide B was made to investigate the importance of that substituent to the HIV-1 inhibitory activity of these coumarins. A total of 14 analogs were isolated or prepared and compared to (+)-calanolide A and (-)-calanolide B in the NCI primary anti-HIV assay. While none of the compounds showed activity superior to the two unmodified leads, some structure-activity requirements were apparent from the relative anti-HIV potencies of the various analogs.