90901-61-4

Basic information

• Product Name: 2,4-bis(3-hydroxybutyl)phenyl isocyanide
• CAS NO: 90901-61-4
• Molecular Weight: 247.337
• Mol File: 90901-61-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,4-bis(3-hydroxybutyl)phenyl isocyanide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-bis(3-hydroxybutyl)phenyl isocyanide(90901-61-4)
• EPA Substance Registry System: 2,4-bis(3-hydroxybutyl)phenyl isocyanide(90901-61-4)

Safety Data

• Hazardous Substances Data: 90901-61-4(Hazardous Substances Data)

Upstream product

• 3100-93-4 2,4-dimethylphenylisocyanide 
• 75-56-9 methyloxirane 

Relevant articles and documents

INDOLE SYNTHESES UTILIZING o-METHYLPHENYL ISOCYANIDES.

New indole synthesis starting with o-methylphenyl isocyanides such as o-tolyl, 2,4-xylyl, and 2,6-xylyl isocyanide is described. Treatment of o-tolyl isocyanide with LDA in diglyme at minus 78 degree C generated selectively o-(lithiomethyl)phenyl isocyanide in an almost quantitative yield, which on warming up to room temperature was cyclized to indole after aqueous workup. Similarly, 2,4-xylyl and 2,6-xylyl and 2,6-xylyl isocyanides were cyclized to 5-methylindole and 7-methylindole quantitatively. The o-(lithiomethyl)phenyl isocyanides reacted with electrophiles such as alkyl halides and alkylene oxides to give o-alkylphenyl isocyanides, which were cyclized via the lithiation at the orthobenzylic carbon to afford 3-substituted indoles.