909115-21-5Relevant articles and documents
"o-Acyl isopeptide method" for peptide synthesis: Synthesis of forty kinds of "o-acyl isodipeptide unit" Boc-Ser/Thr(Fmoc-Xaa)-OH
Yoshiya, Taku,Taniguchi, Atsuhiko,Sohma, Youhei,Fukao, Fukue,Nakamura, Setsuko,Abe, Naoko,Ito, Nui,Skwarczynski, Mariusz,Kimura, Tooru,Hayashi, Yoshio,Kiso, Yoshiaki
, p. 1720 - 1730 (2008/02/10)
The O-acyl isopeptide method has recently received attention as an efficient synthetic method for peptides. Herein, forty kinds of "O-acyl isodipeptide unit" Boc-Ser/Thr(Fmoc-Xaa)-OH (1-40) were effectively synthesized in two-steps without epimerization. The O-acyl isodipeptide units are important building blocks to enable the routine use of the O-acyl isopeptide method. This journal is The Royal Society of Chemistry.
The chemistry of vicinal tricarbonyls: Total syntheses of elastase inhibitors YM-47141 and YM-47142
Wasserman, Harry H.,Chen, Jyun-Hung,Xia, Mingde
, p. 2607 - 2616 (2007/10/03)
We have completed the total syntheses of elastase inhibitors YM-47141 and YM-47142, the first natural products containing a vicinal tricarbonyl group. The work establishes the configuration at C(4) of the macrocyclic depsipeptide and demonstrates the gene