910540-10-2

Basic information

• Product Name: 4-(1-phenylacetyl-piperidin-4-yl)-butyric acid methyl ester
• Synonyms: 4-(1-phenylacetyl-piperidin-4-yl)-butyric acid methyl ester
• CAS NO: 910540-10-2
• Molecular Weight: 303.401
• Mol File: 910540-10-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-(1-phenylacetyl-piperidin-4-yl)-butyric acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1-phenylacetyl-piperidin-4-yl)-butyric acid methyl ester(910540-10-2)
• EPA Substance Registry System: 4-(1-phenylacetyl-piperidin-4-yl)-butyric acid methyl ester(910540-10-2)

Safety Data

• Hazardous Substances Data: 910540-10-2(Hazardous Substances Data)

Upstream product

• 103-80-0 phenylacetyl chloride 

Downstream Products

• 910540-11-3 N-hydroxy-4-(1-phenylacetyl-piperidin-4-yl)-butyramide 

Relevant articles and documents

Alkyl piperidine and piperazine hydroxamic acids as HDAC inhibitors

We report here the strategy used in our research group to find a new class of histone deacetylase (HDAC) inhibitors. A series of N-substituted 4-alkylpiperazine and 4-alkylpiperidine hydroxamic acids, corresponding to the basic structure of HDAC inhibitors (zinc binding moiety-linker-capping group) has been designed, prepared, and tested for HDAC inhibition. Linker length and aromatic capping group connection were systematically varied to find the optimal geometric parameters. A new series of submicromolar inhibitors was thus identified, which showed antiproliferative activity on HCT-116 colon carcinoma cells.

HYDROXAMATES AS HISTONE DEACETYLASE INHIBITORS AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM

Compounds of structure (I) having histone deacetylase (HDAC) inhibitor activity are described. The compounds are chemically characterised by the presence of hydroxamic acid, with zinc as chelator, and an aromatic nucleus connected by a linker in which eit