910581-28-1Relevant articles and documents
Rapid assembly of matrix metalloprotease inhibitors using click chemistry
Wang, Jun,Uttamchandani, Mahesh,Li, Junqi,Hu, Mingyu,Yao, Shao Q.
, p. 3821 - 3824 (2007/10/03)
A panel of 96 metalloprotease inhibitors was assembled using "click chemistry" by reacting eight zinc-binding hydroxamate warheads with 12 azide building blocks. Screens of the bidentate compounds against representative metalloproteases provided discerning inhibition fingerprints, revealing compounds with low micromolar potency against MMP-7. The relative ease and convenience of the strategy in constructing focused chemical libraries for rapid in situ screening of MMPs is thereby demonstrated.