91130-51-7 Usage
Description
4-(2-Bromobenzyl)morpholine, also known as bromobenzylmorpholine, is a chemical compound that features a morpholine ring with a 2-bromobenzyl group attached to it. This structure endows it with unique properties that make it a valuable intermediate in organic synthesis, particularly within the pharmaceutical and agrochemical industries.
Uses
Used in Pharmaceutical Industry:
4-(2-Bromobenzyl)morpholine is used as a key intermediate in the synthesis of various pharmaceutical compounds, including antiviral and antifungal agents. Its unique structure allows for the development of new drugs that can target specific pathogens and diseases, contributing to the advancement of medical treatments.
Used in Agrochemical Industry:
In the agrochemical sector, 4-(2-Bromobenzyl)morpholine serves as an intermediate for the production of compounds that help protect crops from pests and diseases. Its role in creating effective agrochemicals is crucial for ensuring food security and crop yield.
Used in Corrosion Inhibition:
4-(2-Bromobenzyl)morpholine is used as a raw material in the production of corrosion inhibitors. These inhibitors are essential for protecting metal surfaces from degradation, which is particularly important in industries such as automotive, aerospace, and construction.
Used in Organic Synthesis:
As a versatile chemical compound, 4-(2-Bromobenzyl)morpholine is utilized in the preparation of other functionalized morpholine derivatives. These derivatives can be used in a wide range of applications, further expanding the compound's utility in organic chemistry.
Used in Catalysis:
4-(2-Bromobenzyl)morpholine has been investigated for its potential to act as a ligand in various catalytic reactions. Its ability to facilitate these reactions makes it a valuable component in the development of new catalytic processes and the improvement of existing ones, enhancing the efficiency and selectivity of chemical transformations.
Check Digit Verification of cas no
The CAS Registry Mumber 91130-51-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,1,1,3 and 0 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 91130-51:
(7*9)+(6*1)+(5*1)+(4*3)+(3*0)+(2*5)+(1*1)=97
97 % 10 = 7
So 91130-51-7 is a valid CAS Registry Number.
InChI:InChI=1/C11H14BrNO/c12-11-4-2-1-3-10(11)9-13-5-7-14-8-6-13/h1-4H,5-9H2
91130-51-7Relevant articles and documents
Design and synthesis of benzopyran-based inhibitors of the hypoxia-inducible factor-1 pathway with improved water solubility
Ferguson, Jalisa H.,De Los Santos, Zeus,Devi, Saroja N.,Kaluz, Stefan,Van Meir, Erwin G.,Zingales, Sarah K.,Wang, Binghe
, p. 992 - 1001 (2017/08/09)
While progress has been made in treating cancer, cytotoxic chemotherapeutic agents are still the most widely used drugs and are associated with severe side-effects. Drugs that target unique molecular signalling pathways are needed for treating cancer with low or no intrinsic toxicity to normal cells. Our goal is to target hypoxic tumours and specifically the hypoxia inducible factor (HIF) pathway for the development of new cancer therapies. To this end, we have previously developed benzopyran-based HIF-1 inhibitors such as arylsulfonamide KCN1. However, KCN1 and its earlier analogs have poor water solubility, which hamper their applications. Herein, we describe a series of KCN1 analogs that incorporate a morpholine moiety at various positions. We found that replacing the benzopyran group of KCN1 with a phenyl group with a morpholinomethyl moiety at the para positions had minimal effect on potency and improved the water solubility of two new compounds by more than 10-fold compared to KCN1, the lead compound.
