911434-04-3Relevant articles and documents
Preparation method of flumatinib intermediate
-
Paragraph 0034-0037, (2020/10/21)
The invention relates to a preparation method of a flumatinib intermediate, and particularly relates to a synthesis process of an antitumor drug flumatinib intermediate. The preparation method specifically comprises the steps of firstly, synthesizing 4-((4-methylpiperazine-1-yl)methyl)-3-(trifluoromethyl)benzamide(III); secondly, synthesizing 5-bromine-2-methyl-3-nitropyridine(VI); and thirdly, synthesizing N-(6-methyl-5-nitropyridine-3-yl)-4-((4-methylpiperazine-1-yl)methyl)-3-(trifluoromethyl)benzamide(VII). The invention aims to provide a preparation method of the flumatinib intermediate,which is simple to operate, available in raw materials, short in reaction steps, high in yield and environment-friendly.
SPIROCYCLIC INDOLINES AS IL-17 MODULATORS
-
Page/Page column 117, (2019/01/07)
A series of substituted spirocyclic 2-oxoindoline derivatives, and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.
NOVEL SUBSTITUTED PYRIMIDINE COMPOUNDS
-
Page/Page column 110; 111, (2016/02/05)
The invention relates to novel substituted pyrimidine compounds of general formula (I), in which the chemical groupings, substituents, variables and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.