912355-99-8 Usage
Description
(10S,11S)-8-chloro-11-((MethylaMino)Methyl)-10,11-dihydrodibenzo[b,f]oxepine-10-carboxylic acid is a complex organic compound belonging to the class of dibenzo[b,f]oxepine derivatives. It features a unique carbon backbone with a chlorine atom at the 8th position and a carboxylic acid group. Additionally, it contains a methylamino group attached to the 11th position, which contributes to its pharmaceutical properties. (10S,11S)-8-chloro-11-((MethylaMino)Methyl)-10,11-dihydrodibenzo[b,f]oxepine-10-carboxylic acid has potential applications as an anti-inflammatory or psychotropic drug due to its structure and functional groups, and may also be utilized in medicinal chemistry and drug development.
Uses
Used in Pharmaceutical Industry:
(10S,11S)-8-chloro-11-((MethylaMino)Methyl)-10,11-dihydrodibenzo[b,f]oxepine-10-carboxylic acid is used as a potential anti-inflammatory agent for its ability to reduce inflammation and alleviate pain. Its structure and functional groups contribute to its potential therapeutic effects in treating various inflammatory conditions.
Used in Psychotropic Drug Development:
(10S,11S)-8-chloro-11-((MethylaMino)Methyl)-10,11-dihydrodibenzo[b,f]oxepine-10-carboxylic acid is used as a potential psychotropic drug for its ability to modulate neurotransmitter levels and influence brain function. Its unique structure and functional groups may provide new avenues for the development of novel treatments for mental health disorders.
Used in Medicinal Chemistry Research:
(10S,11S)-8-chloro-11-((MethylaMino)Methyl)-10,11-dihydrodibenzo[b,f]oxepine-10-carboxylic acid is used as a research compound in medicinal chemistry to study its pharmacological properties and potential therapeutic uses. Understanding its interactions with biological targets and mechanisms of action can provide valuable insights into the development of new drugs and therapies.
Used in Drug Development:
(10S,11S)-8-chloro-11-((MethylaMino)Methyl)-10,11-dihydrodibenzo[b,f]oxepine-10-carboxylic acid is used in drug development as a lead compound for the design and synthesis of new pharmaceutical agents. Its unique structure and functional groups offer opportunities for optimization and modification to improve potency, selectivity, and safety profiles of potential drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 912355-99-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,2,3,5 and 5 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 912355-99:
(8*9)+(7*1)+(6*2)+(5*3)+(4*5)+(3*5)+(2*9)+(1*9)=168
168 % 10 = 8
So 912355-99-8 is a valid CAS Registry Number.
912355-99-8Relevant articles and documents
Debottlenecking the Synthesis Route of Asenapine
Van Der Linden, Marco,Roeters, Theo,Harling, Ramon,Stokkingreef, Edwin,Gelpke, Arjan Sollewijn,Kemperman, Gerjan
supporting information, p. 196 - 201 (2013/01/03)
The discovery synthesis of asenapine that was used for the manufacture of drug substance batches up to 10 kg contained two chemical steps that were major bottlenecks for scale-up. One of these steps involved a magnesium/methanol reduction of an enamide moiety that was severely hampered by safety and efficiency problems. The other step was a laborious chromatography and isomerization cycle that was marked by a poor yield and extremely low throughput The safety issues of the magnesium/methanol reduction could be solved by adding portions of magnesium to a solution of the enamide. In addition, an alternative process for the conversion of the mixture of cis- and trans-lactam into the desired trans-isomer was developed, circumventing the chromatographic separation.
Intermediate compounds for the prepation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1h-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole
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Page/Page column 3; 7, (2008/06/13)
Disclosed are novel amino acid derivatives of formula (I) and (II) processes for the preparation thereof, and their use in the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino-[4,5-c]pyrrole.
