91245-72-6

Basic information

• Product Name: 1,2,3,4-TETRAHYDRONAPHTHALEN-1-YLMETHYLAMINE
• Synonyms: 1,2,3,4-TETRAHYDRONAPHTHALEN-1-YLMETHYLAMINE;1-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)METHANAMINE;C-(1,2,3,4-TETRAHYDRO-NAPHTHALEN-1-YL)-METHYLAMINE;1,2,3,4-Tetrahydro-1-naphthalenemethanamine
• CAS NO: 91245-72-6
• Molecular Formula: C₁₁H₁₅N
• Molecular Weight: 161.24
• Mol File: 91245-72-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 273 ºC
• Flash Point: 124 ºC
• Appearance: /
• Density: 1.001
• PKA: 9.90±0.29(Predicted)
• CAS DataBase Reference: 1,2,3,4-TETRAHYDRONAPHTHALEN-1-YLMETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3,4-TETRAHYDRONAPHTHALEN-1-YLMETHYLAMINE(91245-72-6)
• EPA Substance Registry System: 1,2,3,4-TETRAHYDRONAPHTHALEN-1-YLMETHYLAMINE(91245-72-6)

Safety Data

• Hazardous Substances Data: 91245-72-6(Hazardous Substances Data)

Usage

General Description

1,2,3,4-Tetrahydronaphthalen-1-ylmethylamine, also known as 1-methylaminotetralin or 1(1-?Methylaminotetralin), is a chemical compound with the molecular formula C12H17N. 1,2,3,4-TETRAHYDRONAPHTHALEN-1-YLMETHYLAMINE features a unique structural attribute – a tetralin (a fused ring system comprised of a six-membered and a five-membered ring) attached to a methylamine group. As with most chemicals, handling this substance would require accurate knowledge of its potential hazards, appropriate safety measures, and storage conditions. However, information on the specific properties, applications, toxicity, or uses of this chemical is minimal and largely unexplored. It should be handled with care, like any other chemical substances.

Upstream product

• 86-53-3 1-Cyanonaphthalene 
• 80096-56-6 (+/-)-1-(aminomethyl)-1-hydroxy-1,2,3,4-tetrahydronaphthalene hydrochloride 
• 25108-63-8 1-methylene-1,2,3,4-tetrahydronaphthalene 
• 64-17-5 ethanol 
• 155566-54-4 1,2,3,4-tetrahydro-1-naphthalenecarbaldehyde 
• 50361-60-9 1-aminomethyl-1-hydroxy-1,2,3,4-tetrahydronaphthalene 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 50361-53-0 1-(trimethylsilyloxy)-1,2,3,4-tetrahydronaphthalene-1-carbonitrile 
• 92367-60-7 1-Oximino-formyl-tetralin 

Downstream Products

• 144-62-7 oxalic acid 
• 88-99-3 benzene-1,2-dicarboxylic acid 
• 98977-64-1 (E)-N-methyl-N-(3-phenyl-2-propenyl)-1,2,3,4-tetrahydro-1-naphthalenemethanamine 

Relevant articles and documents

Direct Access to Primary Amines from Alkenes by Selective Metal-Free Hydroamination

Direct and selective synthesis of primary amines from easily available precursors is attractive yet challenging. Herein, we report the rapid synthesis of primary amines from alkenes via metal-free regioselective hydroamination at room temperature. Ammonium carbonate was used as ammonia surrogate for the first time, allowing for efficient conversion of terminal and internal alkenes into linear, α-branched, and α-tertiary primary amines under mild conditions. This method provides a straightforward and powerful approach to a wide spectrum of advanced, highly functionalized primary amines which are of particular interest in pharmaceutical chemistry and other areas.

Serotonin Receptor Affinity of Cathinone and Related Analogues

A series of cathinone (α-aminopropiophenone) analogues was examined using the isolated rat fundus preparation. (S)-(-)-Cathinone possesses twice the serotonin receptor affinity of (+/-)-cathinone and four times the affinity of racemic amphetamine.Several derivatives of cathinone were found to either possess a lower affinity than the parent compound or did not interact with the receptors in a competitive manner.Several novel analogues, 1-(aminomethyl)-3,4-dihydronaphthalene hydrochloride (3), 4-(aminomethyl)-3-chromene hydrochloride (4b), as well as its 6-methoxy derivative, 4a, interact with serotonin receptors but in a fashion which is, most likely, dissimilar to the interaction of the substituted cathinone analogues.