91273-58-4

Basic information

• Product Name: 3-BENZYLOXY-1-BROMO-2-METHYLPROPANE
• Synonyms: RARECHEM AH CK 0028;3-BENZYLOXY-1-BROMO-2-METHYLPROPANE;((3-broMo-2-Methylpropoxy)Methyl)benzene
• CAS NO: 91273-58-4
• Molecular Formula: C₁₁H₁₅BrO
• Molecular Weight: 243.14
• Mol File: 91273-58-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 264 °C at 760 mmHg
• Flash Point: 114.5 °C
• Appearance: /
• Density: 1.268 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-BENZYLOXY-1-BROMO-2-METHYLPROPANE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BENZYLOXY-1-BROMO-2-METHYLPROPANE(91273-58-4)
• EPA Substance Registry System: 3-BENZYLOXY-1-BROMO-2-METHYLPROPANE(91273-58-4)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 91273-58-4(Hazardous Substances Data)

Usage

General Description

3-BENZYLOXY-1-BROMO-2-METHYLPROPANE is a chemical compound with the molecular formula C11H15BrO. It is a colorless liquid with a molecular weight of 237.14 g/mol. 3-BENZYLOXY-1-BROMO-2-METHYLPROPANE is commonly used as an intermediate in organic synthesis and in the manufacturing of pharmaceuticals. It also has applications in the production of fragrances and flavoring agents. 3-BENZYLOXY-1-BROMO-2-METHYLPROPANE is a versatile chemical that is used in a variety of industries for its reactivity and ability to participate in various chemical reactions. It is important to handle this compound with care and follow safety protocols, as it is considered to be hazardous to human health and the environment.

Upstream product

• 63930-46-1 3-(benzyloxy)-2-methylpropan-1-ol 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 64809-18-3 4-benzyloxy-3-methylbutyronitrile 
• 1073165-11-3 3-benzyloxy-2-methyl-1-propylmagnesium bromide 

Relevant articles and documents

Positron emission tomography to elucidate pharmacokinetic differences of regioisomeric retinoid x receptor agonists

RXR partial agonist NEt-4IB (2a, 6-[ethyl-(4-isobutoxy-3-isopropylphenyl)amino]pyridine-3-carboxylic acid: EC50 = 169 nM, Emax = 55%) showed a blood concentration higher than its Emax after single oral administration at 30 mg/kg to mice, and repeated oral administration at 10 mg/kg/day to KK-Ay mice afforded antitype 2 diabetes activity without the side effects caused by RXR full agonists. However, RXR full agonist NEt-3IB (1a), in which the isobutoxy and isopropyl groups of 2a are interchanged, gave a much lower blood concentration than 2a. Here we used positron emission tomography (PET) with tracers [11C]1a, [11C]2a and fluorinated derivatives [18F]1b, [18F]2b, which have longer half-lives, to examine the reason why 1a and 2a exhibited significantly different blood concentrations. As a result, the reason for the high blood concentration of 2a after oral administration was found to be linked to higher intestinal absorbability together with lower biliary excretion, compared with 1a.

Synthesis of 2,6,10-trimethyl-undecan-1-ol

A synthesis of 2,6,10-trimethyl-undecan-1-ol, an intermediate for producing vitamin E, from methacrolein, crotonaldehyde, β-hydroxy-isobutyric acid including intermediates in this synthesis.