913617-28-4Relevant articles and documents
Total synthesis of (-)-chokol A by an asymmetric domino Michael addition-Dieckmann cyclization
Groth, Ulrich,Kesenheimer, Christian,Kreye, Paul
, p. 2223 - 2226 (2007/10/03)
A convergent and asymmetric total synthesis of (-)-chokol A was accomplished in six steps starting from the α,β-unsaturated ester (E)-9 in an overall yield of 27% with an enantiomeric excess of 95%. The key step of this synthesis is the asymmetric tandem conjugate addition-Dieckmann cyclization of the higher-order cuprate 8 derived from vinyl bromide 7 with the α,β-unsaturated ester (E)-9. Georg Thieme Verlag Stuttgart.