91394-66-0

Basic information

• Product Name: 1-ACETAMIDO-4-BROMONAPHTHALENE
• Synonyms: 1-ACETAMIDO-4-BROMONAPHTHALENE;N-(4-BROMONAPHTHALEN-1-YL)ACETAMIDE;N-(4-BROMONAPHTHALENE-1-YL)-ACETAMIDE;N-ACETYL 4-BROMO-1-NAPHTHYLAMINE;N-(4-Bromo-1-naphthalen-1-yl)acetamide;1-Acetamido-4-bromoonaphthalene;1-Acetamido-4-bromonaphthalene 98%;1-Acetamido-4-bromonaphthalene98%
• CAS NO: 91394-66-0
• Molecular Formula: C₁₂H₁₀BrNO
• Molecular Weight: 264.12
• Product Categories: Amines;blocks;Bromides;Naphthalene derivatives
• Mol File: 91394-66-0.mol
• Article Data: 7

Chemical Properties

• Melting Point: 160-163
• Boiling Point: 454.3 °C at 760 mmHg
• Flash Point: 228.6 °C
• Appearance: /
• Density: 1.528 g/cm³
• Vapor Pressure: 1.92E-08mmHg at 25°C
• Refractive Index: 1.69
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-ACETAMIDO-4-BROMONAPHTHALENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ACETAMIDO-4-BROMONAPHTHALENE(91394-66-0)
• EPA Substance Registry System: 1-ACETAMIDO-4-BROMONAPHTHALENE(91394-66-0)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 91394-66-0(Hazardous Substances Data)

Usage

General Description

1-Acetamido-4-bromonaphthalene is a chemical compound that consists of a naphthalene ring with an acetamide group at the 1-position and a bromine atom at the 4-position. It is commonly used in the synthesis of organic compounds and pharmaceutical products. The presence of the bromine atom makes 1-acetamido-4-bromonaphthalene useful as a reagent in various organic reactions, particularly in the formation of carbon-carbon bonds. The acetamide group also lends the compound to use as a protecting group for amines in organic synthesis. Its chemical and physical properties make it a versatile and important building block in the production of a wide range of materials and products.

InChI:InChI=1/C12H10BrNO/c1-8(15)14-12-7-6-11(13)9-4-2-3-5-10(9)12/h2-7H,1H3,(H,14,15)

Upstream product

• 575-36-0 1-acetamidonaphthalene 
• 2298-07-9 4-Bromo-1-naphthylamine 
• 64-19-7 acetic acid 
• 108-24-7 acetic anhydride 
• 134-32-7 1-amino-naphthalene 
• 75-05-8 acetonitrile 
• 67-66-3 chloroform 
• 115348-05-5 1-acetamido-5,8-dihydronaphthalene 
• 7726-95-6 bromine 
• 861294-59-9 N-(4,6,7-tribromo-5,6,7,8-tetrahydro-[1]naphthyl)-acetamide 
• 6255-94-3 1-acetylamino-4-naphthalenesulfonic acid 
• 77-48-5 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione 
• 7072-23-3 1,3-dibromo-5,5-dimethyl-hydantoin 
• 67-56-1 methanol 

Downstream Products

• 1578179-15-3 2-(4-iodonaphthalen-2-ylamino)-5-nitrobenzoic acid 
• 1397751-60-8 (E)-1-(6-bromo-2-styrylbenzo[cd]indol-1(2H)-yl)ethanone 
• 1397751-57-3 (E)-N-(4-bromo-8-styrylnaphthalen-1-yl)acetamide 
• 58149-72-7 1-(3-Chlor-1-naphthyl)-ethanol 

Relevant articles and documents

KRAS G12D INHIBITORS

The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.

Preparation method of high-purity 1,4-dibromonaphthalene

The invention relates to a preparation method of high-purity 1,4-dibromonaphthalene and belongs to the technical field of organic synthesis. The provided preparation method of high-purity 1,4-dibromonaphthalene aims to solve the problems that preparation methods of 1,4-dibromonaphthalene in the prior art are complicated, the reaction conditions are high, the product purity is low, the yield is low, and the product quality is unstable. The method comprises the four steps of a one-pot acetylation protection and selective bromination process, a hydrolysis deprotection process, a diazotization coupling reaction process and a recrystallization purification process to obtain high-purity 1,4-dibromonaphthalene. The provided preparation method has the advantages that the synthesis route is short,the reaction conditions are mild and easy to control, and the production cost is low. The organic synthesis reaction site is monotonous, the selectivity is high, the product purity is up to 99.0%, andthe total yield can reach 71.7%. Industrial production is easily realized, the need for large-scale production of 1,4-dibromonaphthalene can be effectively met, and the method has a broad applicationprospect.

Monna, a potent and selective blocker for transmembrane protein with unknown function 16/anoctamin-1

Transmembrane protein with unknown function 16/anoctamin-1 (ANO1) is a protein widely expressed in mammalian tissues, and it has the properties of the classic calcium-activated chloride channel (CaCC). This protein has been implicated in numerous major physiological functions. However, the lack of effective and selective blockers has hindered a detailed study of the physiological functions of this channel. In this study, we have developed a potent and selective blocker for endogenous ANO1 in Xenopus laevis oocytes (xANO1) using a drug screening method we previously established (Oh et al., 2008). We have synthesized a number of anthranilic acid derivatives and have determined the correlation between biological activity and the nature and position of substituents in these derived compounds. A structure-activity relationship revealed novel chemical classes of xANO1 blockers. The derivatives contain a-NO2 group on position 5 of a naphthyl group-substituted anthranilic acid, and they fully blocked xANO1 chloride currents with an IC 5050 of 0.08 μM for xANO1. Selectivity tests revealed that other chloride channels such as bestrophin-1, chloride channel protein 2, and cystic fibrosis transmembrane conductance regulator were not appreciably blocked by 10～30 μM MONNA. The potent and selective blockers for ANO1 identified here should permit pharmacological dissection of ANO1/CaCC function and serve as potential candidates for drug therapy of related diseases such as hypertension, cystic fibrosis, bronchitis, asthma, and hyperalgesia.