913969-24-1

Basic information

• Product Name: N-(2,5-di-tert-butylphenyl)-3-(2-bromophenyl)propanamide
• Synonyms: N-(2,5-di-tert-butylphenyl)-3-(2-bromophenyl)propanamide
• CAS NO: 913969-24-1
• Molecular Weight: 416.401
• Mol File: 913969-24-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(2,5-di-tert-butylphenyl)-3-(2-bromophenyl)propanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,5-di-tert-butylphenyl)-3-(2-bromophenyl)propanamide(913969-24-1)
• EPA Substance Registry System: N-(2,5-di-tert-butylphenyl)-3-(2-bromophenyl)propanamide(913969-24-1)

Safety Data

• Hazardous Substances Data: 913969-24-1(Hazardous Substances Data)

Upstream product

• 21860-03-7 2,5-di-tert-butylaniline 
• 135613-33-1 3-(2-bromophey)propionic acid ethyl ester 

Relevant articles and documents

Highly enantioselective synthesis of atropisomeric anilide derivatives through catalytic asymmetric N-arylation: Conformational analysis and application to asymmetric enolate chemistry

In the presence of (R)-DTBM-SEGPHOS-Pd(OAc)2 catalyst, N-arylation (aromatic amination) of various o-tert-butylanilides with p-iodonitrobenzene proceeds with high enantioselectivity (88-96% ee) to give atropisomeric N-(p-nitrophenyl)anilides having an N-C chiral axis in good yields. Atropisomeric anilide products highly prefer to exist as the E-rotamer which has trans-disposed o-tert-butylphenyl group and carbonyl oxygen. The application of the present catalytic enantioselective N-arylation to an intramolecular version gives atropisomeric lactam derivatives with high optical purity (92-98% ee). The reaction of the lithium enolate prepared from the atropisomeric anilide and lactam products with various alkyl halides gives α-alkylated products with high diastereoselectivity (diastereomer ratio = 13:1 to 46:1).