914089-60-4

Basic information

• Product Name: 1-(2-Amino-3,6-dichloro-phenyl)-ethanone
• Synonyms: 1-(2-Amino-3,6-dichloro-phenyl)-ethanone
• CAS NO: 914089-60-4
• Molecular Weight: 204.056
• Mol File: 914089-60-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(2-Amino-3,6-dichloro-phenyl)-ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-Amino-3,6-dichloro-phenyl)-ethanone(914089-60-4)
• EPA Substance Registry System: 1-(2-Amino-3,6-dichloro-phenyl)-ethanone(914089-60-4)

Safety Data

• Hazardous Substances Data: 914089-60-4(Hazardous Substances Data)

Upstream product

• 3032-32-4 3,6-dichloroanthranilic acid 
• 917-54-4 methyllithium 
• 914089-59-1 2-Amino-3,6-dichloro-N-methoxy-N-methyl-benzamide 

Relevant articles and documents

Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: Structure-activity relationship elucidation

The optimisation of affinity and selectivity in a novel series of dual 5-HT5A/5-HT7 receptor ligands is described. Brain penetrant 2-aminodihydroquinazolines with low nanomolar affinities were identified.

(3,4-Dihydro-quinazolin-2-yl)-(2-aryloxy-ethyl)-amine

The present invention relates to compounds of formula I wherein R, R1, R2, R3, R4, aryl, n, and m are as defined in the specification and pharmaceutically acceptable acid addition salts and tautomeric forms thereof. Such compounds have good activity on the 5-HT5A receptor. Therefore, the invention provides methods for the treatment of certain CNS disorders with such compounds.