914251-05-1Relevant articles and documents
Three groups good, four groups bad? Atropisomerism in ortho-substituted diaryl ethers
Betson, Mark S.,Clayden, Jonathan,Worrall, Christopher P.,Peace, Simon
, p. 5803 - 5807 (2007/10/03)
(Chemical Equation Presented) Bring on the substitute: Even outside of macrocyclic structures, such as vancomycin, appropriate substitution can give rise to atropisomerism in diaryl ethers. Stereochemical stability about the Ar-OAr axis at room temperature or above is possible when neither of the rings is symmetrically substituted and when at least one ring carries an ortho tert-butyl group or equivalent.