914262-79-6

Basic information

• Product Name: 2-Naphthalenecarbonitrile, 7-[5-(4-cyanophenyl)-2-furanyl]-3,4-dihydro-
• CAS NO: 914262-79-6
• Molecular Formula: C22H14N2O
• Molecular Weight: 322.366
• Mol File: 914262-79-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Naphthalenecarbonitrile, 7-[5-(4-cyanophenyl)-2-furanyl]-3,4-dihydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Naphthalenecarbonitrile, 7-[5-(4-cyanophenyl)-2-furanyl]-3,4-dihydro-(914262-79-6)
• EPA Substance Registry System: 2-Naphthalenecarbonitrile, 7-[5-(4-cyanophenyl)-2-furanyl]-3,4-dihydro-(914262-79-6)

Safety Data

• Hazardous Substances Data: 914262-79-6(Hazardous Substances Data)

Upstream product

• 914262-78-5 2-(2-cyano-3,4-dihydronaphthalen-7-yl)furan 
• 623-00-7 4-bromobenzenecarbonitrile 
• 914262-72-9 ethyl 7-bromo-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate 
• 6340-79-0 4-oxo-4-(4-bromophenyl)butanoic acid 
• 35656-89-4 4-(4-bromophenyl)butanoic acid 
• 32281-97-3 7-bromo-3,4-dihydro-2H-naphthalen-1-one 
• 914262-74-1 7-bromo-2-hydroxymethyl-1,2,3,4-tetrahydronaphthalen-1-ol 
• 914262-76-3 7-bromo-2-hydroxymethyl-3,4-dihydronaphthalene 
• 914262-75-2 7-bromo-2-chloromethyl-3,4-dihydronaphthalene 
• 914262-77-4 7-bromo-2-cyano-3,4-dihydronaphthalene 

Downstream Products

• 914336-50-8 2-(2-N-hydroxyamidino-3,4-dihydronaphthalen-7-yl)-5-(4-N-hydroxyamidinophenyl)furan 

Relevant articles and documents

Dicationic DNA-targeted antiprotozoal agents: Naphthalene replacement of benzimidazole

A series of naphthalene analogues of highly active benzimidazole diamidines were synthesized using sequential Stille and Suzuki coupling reactions for preparation of the bis-nitrile intermediates. All of the diamidines showed strong DNA affinities as judged by high ΔTm values with poly(dA-dT). The dicationic compounds were quite active in vitro versus Trypanosoma brucei rhodesiense (T. b. r.) exhibiting IC50 values ranging from 4 to 98 nM. These compounds were also active versus Plasmodium falciparum (P. f.) giving IC50 values ranging from 4 to 33 nM. Two of the compounds showed good activity in vivo in the STIB900 model for acute African trypanosomiasis; one gave 3/4 cures and the other gave 4/4 cures on ip dosage of 20 mg/kg for 4 days. The amidoxime prodrugs of the naphthalene analogues were essentially ineffective.