91430-80-7

Basic information

• Product Name: N,N-Dimethyl-3-(4-nitrophenoxy)-1-propanamine
• Synonyms: N,N-DIMETHYL-3-(4-NITROPHENOXY)-1-PROPANAMINE;N,N-Dimethyl-3-(4-nitrophenoxy)propylamine;N,N-dimethyl-3-(4-nitrophenoxy)propan-1-amine;N,N-Dimethyl-3-(4-nitrophenoxy)-1-propanamineHCl;1-Propanamine, N,N-dimethyl-3-(4-nitrophenoxy)-;N,N-Dimethyl-3-(4-nitrophenoxy)-1-propamine
• CAS NO: 91430-80-7
• Molecular Formula: C₁₁H₁₆N₂O₃
• Molecular Weight: 224.26
• Product Categories: API intermediates
• Mol File: 91430-80-7.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 340.787 °C at 760 mmHg
• Flash Point: 159.902 °C
• Appearance: /
• Density: 1.129 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.534
• CAS DataBase Reference: N,N-Dimethyl-3-(4-nitrophenoxy)-1-propanamine(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-Dimethyl-3-(4-nitrophenoxy)-1-propanamine(91430-80-7)
• EPA Substance Registry System: N,N-Dimethyl-3-(4-nitrophenoxy)-1-propanamine(91430-80-7)

Safety Data

• Hazardous Substances Data: 91430-80-7(Hazardous Substances Data)

Usage

General Description

N,N-Dimethyl-3-(4-nitrophenoxy)-1-propanamine is a chemical compound that belongs to the class of amines. It is composed of a propanamine molecule with a 4-nitrophenoxy group attached at the third carbon and two methyl groups attached to the nitrogen atom. N,N-Dimethyl-3-(4-nitrophenoxy)-1-propanamine is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also a versatile building block in organic chemistry and can be used in the production of various other chemicals. Additionally, it has potential applications in research and development, such as in the study of chemical reactions and the development of new compounds.

InChI:InChI=1/C11H16N2O3/c1-12(2)8-3-9-16-11-6-4-10(5-7-11)13(14)15/h4-7H,3,8-9H2,1-2H3

Upstream product

• 100-02-7 4-nitro-phenol 
• 5407-04-5 3-(dimethylamino)propyl chloride hydrochloride 
• 79096-54-1 1-(3-Chloropropoxy)-4-nitrobenzene 
• 124-40-3 dimethyl amine 
• 3179-63-3 3-Dimethylamino-1-propanol 
• 350-46-9 4-Fluoronitrobenzene 
• 506-59-2 N,N-dimethylammonium chloride 
• 109-54-6 3-(Dimethylamino)propyl chloride 
• 1124-31-8 potassium 4-nitrophenolate 

Downstream Products

• 128457-37-4 N-(6,11-dihydrodibenzothiepin-11-yl)-4-(3-dimethylaminopropoxy)aniline 
• 98596-52-2 (4-Bromo-benzyl)-dimethyl-[3-(4-nitro-phenoxy)-propyl]-ammonium; bromide 
• 98596-68-0 (4-Chloro-benzyl)-dimethyl-[3-(4-nitro-phenoxy)-propyl]-ammonium; chloride 
• 98596-65-7 Dimethyl-(4-nitro-benzyl)-[3-(4-nitro-phenoxy)-propyl]-ammonium; chloride 
• 98740-92-2 Benzyl-dimethyl-[3-(4-nitro-phenoxy)-propyl]-ammonium; bromide 

Relevant articles and documents

With anti-tumor activity of a biphenyl amide compound and its preparation method and application

The invention discloses a biphenyl amide compound with antitumor activity as well as a preparation method and application thereof. The structural formula of the compound is shown in the specification, wherein in the structural formula, R1 is hydrogen or halogen; R2 is alkoxy with carbon number of 1-4; the terminal of R2 is replaced by tert-amido; R2 is linked to the para-position of amide via an oxygen atom. The compound has good tumor cell inhibiting activity in vitro and can be used for preparing antitumor drugs, especially anti-hepatoma drugs and anti-breast cancer drugs. The preparation method of the biphenyl amide compound, provided by the invention, has the advantages that the raw materials are accessible, the reaction conditions are mild, the reaction process is simple to operate, and the used reagent is cheap.

Design, synthesis and biological evaluation of pyridin-3-yl pyrimidines as potent Bcr-Abl inhibitors

A series of pyridin-3-yl pyrimidines was synthesized and evaluated for their Bcr-Abl inhibitory and anticancer activity. The preliminary results indicated that some compounds were promising anticancer agents. Compounds A2, A8, and A9 exhibited potent Bcr-Abl inhibitory activity, suggesting that aniline containing halogen substituents might be important for biological activity. Molecular docking was carried out to investigate the binding mode of them with Bcr-Abl. Details of synthesis and SAR studies of these compounds are described. A series of phenylaminopyrimidines was designed and synthesized as potent Bcr-Abl inhibitors. The screening of these rationally designed compounds for antitumor activity had identified three candidate leads which could be further optimized to improve the anticancer activities.

INDOLINONE DERIVATIVES AND THEIR USE IN TREATING DISEASE-STATES SUCH AS CANCER

The present invention encompasses compounds of general formula (1) wherein R1 to R4 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a pharmaceutical composition having the above-mentioned properties.