914637-31-3

Basic information

• Product Name: 3-Fluoro-5-methoxyphenylacetonitrile
• Synonyms: 3-Fluoro-5-Methoxybenzyl cyanide;2-(3-Fluoro-5-Methoxyphenyl)acetonitrile;3-Fluoro-5-methoxybenzyl cyanide, 3-(Cyanomethyl)-5-fluoroanisole
• CAS NO: 914637-31-3
• Molecular Formula: C₉H₈FNO
• Molecular Weight: 165.1643232
• Mol File: 914637-31-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 249℃
• Flash Point: 105℃
• Appearance: /
• Density: 1.148
• CAS DataBase Reference: 3-Fluoro-5-methoxyphenylacetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Fluoro-5-methoxyphenylacetonitrile(914637-31-3)
• EPA Substance Registry System: 3-Fluoro-5-methoxyphenylacetonitrile(914637-31-3)

Safety Data

• RIDADR: 2810
• HazardClass: 6.1
• PackingGroup: Ⅲ
• Hazardous Substances Data: 914637-31-3(Hazardous Substances Data)

Usage

Chemical Properties

Colorless Liquid

Upstream product

• 1214346-07-2 1-(chloromethyl)-3-fluoro-5-methoxybenzene 
• 455-40-3 3,5-difluorobenzoic acid 
• 176548-72-4 3-fluoro-5-methoxybenzoic acid 
• 914637-27-7 (3-fluoro-5-methoxyphenyl)methanol 
• 202925-08-4 1-chloro-3-fluoro-5-methoxybenzene 
• 105-56-6 ethyl 2-cyanoacetate 
• 29578-39-0 1-bromo-3-fluoro-5-methoxybenzene 
• 7677-24-9 trimethylsilyl cyanide 
• 914637-29-9 1-(bromomethyl)-3-fluoro-5-methoxybenzene 
• 143-33-9 sodium cyanide 

Downstream Products

• 914637-33-5 2-(3-fluoro-5-methoxyphenyl)acetic acid 
• 1352306-24-1 1-(2,5-dimethoxyphenyl)-2-(3-fluoro-5-methoxyphenyl)ethanone 
• 1564236-75-4 ethyl 2-cyano-2-(3-fluoro-5-methoxyphenyl)acetate 
• 1564237-15-5 5-amino-4-(3-fluoro-5-methoxyphenyl)-1-methyl-1H-pyrazol-3-ol 
• 1564226-00-1 1-(2-chlorophenyl)-8-fluoro-6-methoxy-3-methyl-3H-pyrazolo[3,4-c]cinnoline 

Relevant articles and documents

Assembly of α-(Hetero)aryl Nitriles via Copper-Catalyzed Coupling Reactions with (Hetero)aryl Chlorides and Bromides

α-(Hetero)aryl nitriles are important structural motifs for pharmaceutical design. The known methods for direct synthesis of these compounds via coupling with (hetero)aryl halides suffer from narrow reaction scope. Herein, we report that the combination of copper salts and oxalic diamides enables the coupling of a variety of (hetero)aryl halides (Cl, Br) and ethyl cyanoacetate under mild conditions, affording α-(hetero)arylacetonitriles via one-pot decarboxylation. Additionally, the CuBr/oxalic diamide catalyzed coupling of (hetero)aryl bromides with α-alkyl-substituted ethyl cyanoacetates proceeds smoothly at 60 °C, leading to the formation of α-alkyl (hetero)arylacetonitriles after decarboxylation. The method features a general substrate scope and is compatible with various functionalities and heteroaryls.

ESTROGEN RECEPTOR MODULATORS AND USES THEREOF

Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

NOVEL COMPOUNDS

The invention relates to substituted phenylacetic acids as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.