914948-32-6

Basic information

• Product Name: 3-fluoro-5-(2-(trimethylsilyl)ethynyl)benzonitrile
• Synonyms: 3-fluoro-5-(2-(trimethylsilyl)ethynyl)benzonitrile
• CAS NO: 914948-32-6
• Molecular Weight: 217.318
• Mol File: 914948-32-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-fluoro-5-(2-(trimethylsilyl)ethynyl)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-fluoro-5-(2-(trimethylsilyl)ethynyl)benzonitrile(914948-32-6)
• EPA Substance Registry System: 3-fluoro-5-(2-(trimethylsilyl)ethynyl)benzonitrile(914948-32-6)

Safety Data

• Hazardous Substances Data: 914948-32-6(Hazardous Substances Data)

Upstream product

• 179898-34-1 3-bromo-5-fluorobenzonitrile 
• 1066-54-2 trimethylsilylacetylene 

Downstream Products

• 945933-47-1 5-fluoro-3-(2-(2-(tert-butyldimethylsilyloxymethyl)thiazol-4-yl)ethynyl)benzonitrile 
• 872122-56-0 3-ethynyl-5-fluorobenzonitrile 
• 1380072-56-9 6-hydroxymethyl-2-[(3-cyano-5-fluorophenyl)ethynyl]pyridine 
• 1380072-62-7 6-fluoro-2-[(3-cyano-5-fluorophenyl)ethynyl]pyridine 
• 1380072-58-1 6-methoxy-2-[(3-cyano-5-fluorophenyl)ethynyl]pyridine 
• 1380072-60-5 6-acetyl-2-[(3-cyano-5-fluorophenyl)ethynyl]pyridine 
• 1380072-78-5 BrH*C₁₅H₈FN₃O 
• 1380072-89-8 BrH*C₁₅H₉FN₂O 
• 1380072-87-6 BrH*C₁₅H₆FN₃ 
• 1380072-76-3 5-fluoro-3-[(6-cyanopyridin-2-yl)ethynyl]benzamide 
• 1380072-54-7 6-cyano-2-[(3-cyano-5-fluorophenyl)ethynyl]pyridine 
• 945933-48-2 3-fluoro-5-(2-(2-(hydroxymethyl)thiazol-4-yl)ethynyl)benzonitrile 
• 945933-49-3 3-(2-(2-(bromomethyl)thiazol-4-yl)ethynyl)-5-fluorobenzonitrile 

Relevant articles and documents

Metabotropic glutamate receptor 5 negative allosteric modulators as novel tools for in vivo investigation

Negative allosteric modulators (NAMs) of metabotropic glutamate receptor subtype 5 (mGluR5) have shown promising results in preclinical models for anxiety and drug abuse. Here, we describe a series of aryl-substituted alkynyl analogues of the prototypic m

1, 6 -DIHYDRO- 1,3, 5, 6-TETRAAZA-AS-INDACENE BASED TRICYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME AS INHIBITORS OF IKK ENZYME ACTIVITY

The present invention provides for tricyclic compounds having the formula (I) wherein R1, R2, R5, R6, R7, and R8 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.